1 Overview

Data

Normalization

Model options

Network processing

cor/cov method: pearson

2 Load and normalize data

Data

Normalization

2.1 Load TCGA data

See prepare.tcga.survival.data function for how to configure parameters.

This uses data packages from obtained from ‘github:averissimo/tcga’ that contain FPKM expression levels.

prepare.tcga.survival.data('skcm.data.2018.09.11',
                           'metastatic',
                            normalization        = 'center',
                            log2.pre.normalize   = TRUE,
                            handle.duplicates    = 'keep_first',
                            coding.genes         = TRUE,
                            subtract.surv.column = 'days_to_submitted_specimen_dx')

2.1.1 Summary of data

## [INFO]        Loaded data from TCGA: skcm.data.2018.09.11
## [INFO]               type of tissue: metastatic
## [INFO]   observations (individuals): 351 (174 event / 177 censored)
## [INFO]            variables (genes): 19844

2.1.2 Survival curve

2.2 Load degree data

Network processing

  • Degree calculation: string
  • Edge cutoff: 0
  • Unweighted edges

cor/cov method: pearson

  • only applies if network type is correlation/covariance

2.3 Preparing degree vector

  • Normalize degree between 0 and 1
  • Hub: heuristic( 1 - degree )
  • Orphan: heuristic( degree )
  • trans.fun is a double power to scale the values

see ?glmSparseNet::heuristicScale or ?glmSparseNet::hubHeuristic

# see ?glmSparseNet::heuristic.scale
trans.fun <- function(x) {
    heuristicScale(x) + 0.2
}

2.3.1 Genes with degree above 4000

ensembl_gene_id degree external_gene_name
ENSG00000150991 10394 ENSG00000150991
ENSG00000170325 6346 ENSG00000170325
ENSG00000100300 5797 ENSG00000100300
ENSG00000174775 5614 ENSG00000174775
ENSG00000142208 5573 ENSG00000142208
ENSG00000111640 5363 ENSG00000111640
ENSG00000163631 5260 ENSG00000163631
ENSG00000177606 4952 ENSG00000177606
ENSG00000141510 4936 ENSG00000141510
ENSG00000197122 4903 ENSG00000197122
ENSG00000254647 4592 ENSG00000254647
ENSG00000112062 4187 ENSG00000112062
ENSG00000170315 4114 ENSG00000170315
ENSG00000170345 4010 ENSG00000170345

2.3.2 Original degree frequency

Original

LOG10 Scale on X-axis

3 Model Inference

3.1 Train and test sets

## [INFO] Size of sets: (size/events)
##  * Train: 80.00% ::  280 /  139
##  *  Test: 20.00% ::   71 /  35
## [INFO] Number of variables per model:
Model BaseModel Alpha TargetVars nvars
Elastic Net Elastic Net 0.10 116 116
Hub Elastic Net 0.10 116 116
Orphan Elastic Net 0.10 116 116
Elastic Net Hub 0.10 41 41
Hub Hub 0.10 41 43
Orphan Hub 0.10 41 42
Elastic Net Orphan 0.10 111 116
Hub Orphan 0.10 111 113
Orphan Orphan 0.10 111 116
## [INFO] note, selected variables could be slightly different from target, to have more accuracy increase nlambda in code

4 Results

4.1 Relative risk distribution

Calculated using the inferred models and the train/test datasets. The higher the better.

Test Set

Train Set

4.2 Kaplan-Meier Curves

4.2.1 Models on test sets

Elastic Net (base model: Elastic Net)

Test set

Training set

Hub (base model: Elastic Net)

Test set

Training set

Orphan (base model: Elastic Net)

Test set

Training set

Elastic Net (base model: Hub)

Test set

Training set

Hub (base model: Hub)

Test set

Training set

Orphan (base model: Hub)

Test set

Training set

Elastic Net (base model: Orphan)

Test set

Training set

Hub (base model: Orphan)

Test set

Training set

Orphan (base model: Orphan)

Test set

Training set

4.3 Summary Table

weighted penalization project tissue cutoff coding.genes alpha model nvars km.train km.test c.index.train c.index.test
FALSE string skcm.data.2018.09.11 metastatic 0 TRUE 0.10 Elastic Net 116 0 0.0220258 0.7563888 0.7043236
FALSE string skcm.data.2018.09.11 metastatic 0 TRUE 0.10 Hub 116 0 0.0298483 0.7752908 0.6799163
FALSE string skcm.data.2018.09.11 metastatic 0 TRUE 0.10 Orphan 116 0 0.0086090 0.7695189 0.7147838
FALSE string skcm.data.2018.09.11 metastatic 0 TRUE 0.10 Elastic Net 41 0 0.0008160 0.6812654 0.6917713
FALSE string skcm.data.2018.09.11 metastatic 0 TRUE 0.10 Hub 43 0 0.0013825 0.6873017 0.7196653
FALSE string skcm.data.2018.09.11 metastatic 0 TRUE 0.10 Orphan 42 0 0.0039169 0.6884032 0.6757322
FALSE string skcm.data.2018.09.11 metastatic 0 TRUE 0.10 Elastic Net 116 0 0.0220258 0.7563888 0.7043236
FALSE string skcm.data.2018.09.11 metastatic 0 TRUE 0.10 Hub 113 0 0.0298483 0.7697832 0.6827057
FALSE string skcm.data.2018.09.11 metastatic 0 TRUE 0.10 Orphan 116 0 0.0086090 0.7695189 0.7147838

4.4 Non-zero genes

4.4.1 Venn Diagram of selected genes

4.4.1.1 Overlap between models (with same target number of variables)

Base model: Elastic Net with Target Vars: 116 and Alpha: 0.10

Base model: Hub with Target Vars: 41 and Alpha: 0.10

Base model: Orphan with Target Vars: 111 and Alpha: 0.10

Table of genes in models

(not running at the moment)

5 5000 Runs

5.1 C-Index distribution

Test set

Summary of C-Index and Log-rank

metric model base.model target.vars alpha mean std median min
C-Index (Test set) Hub Elastic Net 116 0.10 0.624 0.042 0.625 0.473
C-Index (Test set) Hub Hub 41 0.10 0.631 0.042 0.632 0.476
C-Index (Test set) Hub Orphan 111 0.10 0.624 0.042 0.626 0.474
C-Index (Test set) Elastic Net Elastic Net 116 0.10 0.640 0.040 0.641 0.486
C-Index (Test set) Elastic Net Hub 41 0.10 0.648 0.041 0.649 0.474
C-Index (Test set) Elastic Net Orphan 111 0.10 0.641 0.040 0.641 0.487
C-Index (Test set) Orphan Elastic Net 116 0.10 0.645 0.041 0.646 0.48
C-Index (Test set) Orphan Hub 41 0.10 0.645 0.042 0.646 0.468
C-Index (Test set) Orphan Orphan 111 0.10 0.645 0.041 0.646 0.48
Log-rank (Test set) Hub Elastic Net 116 0.10 0.127 0.195 0.043 7.3e-07
Log-rank (Test set) Hub Hub 41 0.10 0.105 0.172 0.030 3.22e-07
Log-rank (Test set) Hub Orphan 111 0.10 0.125 0.193 0.042 7.3e-07
Log-rank (Test set) Elastic Net Elastic Net 116 0.10 0.100 0.171 0.028 1.41e-08
Log-rank (Test set) Elastic Net Hub 41 0.10 0.098 0.169 0.027 5.46e-08
Log-rank (Test set) Elastic Net Orphan 111 0.10 0.099 0.168 0.028 3.01e-08
Log-rank (Test set) Orphan Elastic Net 116 0.10 0.087 0.157 0.020 1.08e-08
Log-rank (Test set) Orphan Hub 41 0.10 0.091 0.161 0.023 4.92e-09
Log-rank (Test set) Orphan Orphan 111 0.10 0.086 0.157 0.021 8.75e-09

C-Index Distribution

Rank

Elastic Net vs Hub
base.model r.squared
Elastic Net with target nvars: 116 alpha: 0.10 0.4719617
Hub with target nvars: 41 alpha: 0.10 0.4067332
Orphan with target nvars: 111 alpha: 0.10 0.4730481

Elastic Net vs. Orphan
base.model r.squared
Elastic Net with target nvars: 116 alpha: 0.10 0.9117127
Hub with target nvars: 41 alpha: 0.10 0.9219959
Orphan with target nvars: 111 alpha: 0.10 0.9130622

Hub vs. Orphan
base.model r.squared
Elastic Net with target nvars: 116 alpha: 0.10 0.4395095
Hub with target nvars: 41 alpha: 0.10 0.4054032
Orphan with target nvars: 111 alpha: 0.10 0.4401935

Train set

Summary of C-Index and Log-rank

metric model base.model target.vars alpha mean std median min
C-Index (Train set) Hub Elastic Net 116 0.10 0.791 0.010 0.791 0.76
C-Index (Train set) Hub Hub 41 0.10 0.707 0.010 0.707 0.673
C-Index (Train set) Hub Orphan 111 0.10 0.786 0.010 0.786 0.754
C-Index (Train set) Elastic Net Elastic Net 116 0.10 0.778 0.010 0.778 0.745
C-Index (Train set) Elastic Net Hub 41 0.10 0.702 0.010 0.702 0.66
C-Index (Train set) Elastic Net Orphan 111 0.10 0.774 0.010 0.774 0.745
C-Index (Train set) Orphan Elastic Net 116 0.10 0.790 0.010 0.790 0.754
C-Index (Train set) Orphan Hub 41 0.10 0.707 0.011 0.707 0.673
C-Index (Train set) Orphan Orphan 111 0.10 0.786 0.010 0.786 0.748
Log-rank (Train set) Hub Elastic Net 116 0.10 0.000 0.000 0.000 0
Log-rank (Train set) Hub Hub 41 0.10 0.000 0.000 0.000 0
Log-rank (Train set) Hub Orphan 111 0.10 0.000 0.000 0.000 0
Log-rank (Train set) Elastic Net Elastic Net 116 0.10 0.000 0.000 0.000 0
Log-rank (Train set) Elastic Net Hub 41 0.10 0.000 0.000 0.000 1.22e-15
Log-rank (Train set) Elastic Net Orphan 111 0.10 0.000 0.000 0.000 0
Log-rank (Train set) Orphan Elastic Net 116 0.10 0.000 0.000 0.000 0
Log-rank (Train set) Orphan Hub 41 0.10 0.000 0.000 0.000 0
Log-rank (Train set) Orphan Orphan 111 0.10 0.000 0.000 0.000 0

C-Index Distribution

C-Index Rank

5.2 Log-rank test on Kaplan-Meier models

5.2.1 Log-Rank distribution

Cumulative

Distribution of Log-rank test with groups separated by high and low risk groups

Distribution

Distribution of Log-rank test with groups separated by high and low risk groups

5.2.2 Log-Rank Rank

5.2.2.1 Elastic Net vs Hub

base.model r.squared
Elastic Net with target nvars: 116 alpha: 0.10 0.1828148
Hub with target nvars: 41 alpha: 0.10 0.1989902
Orphan with target nvars: 111 alpha: 0.10 0.1832092

5.2.2.2 Elastic Net vs. Orphan

base.model r.squared
Elastic Net with target nvars: 116 alpha: 0.10 0.6372866
Hub with target nvars: 41 alpha: 0.10 0.6644938
Orphan with target nvars: 111 alpha: 0.10 0.6347008

5.2.2.3 Hub vs. Orphan

base.model r.squared
Elastic Net with target nvars: 116 alpha: 0.10 0.1585745
Hub with target nvars: 41 alpha: 0.10 0.2080129
Orphan with target nvars: 111 alpha: 0.10 0.1613894

5.3 Consesus genes

5.3.1 Selected genes over all runs

Bar plots of frequencies

Overlap between variables selected

Base model: Elastic Net with Target Vars: 116 and Alpha: 0.10

Base model: Hub with Target Vars: 41 and Alpha: 0.10

Base model: Orphan with Target Vars: 111 and Alpha: 0.10

5.3.2 Selected genes in significant runs

i.e. with pvalue < 0.05 in Log-rank test using the test set.

Bar plots of frequencies

Overlap between variables selected

5.3.2.0.1 Base model Elastic Net with target nvars: 0.10 alpha: 116

5.3.2.0.2 Base model Hub with target nvars: 0.10 alpha: 41

5.3.2.0.3 Base model Orphan with target nvars: 0.10 alpha: 111

5.3.3 Genes in Significant runs

i.e. with pvalue < 0.05 in Log-rank test using the test set.

Top consensus 20 genes

Gene Overlap total
ENSG00000140511 2 18861
ENSG00000189013 2 18829
ENSG00000108700 2 18743
ENSG00000185885 2 17282
ENSG00000174885 2 15713
ENSG00000159618 2 15272
ENSG00000156265 2 14971
ENSG00000204642 2 14514
ENSG00000100918 2 13128
ENSG00000231389 2 12455
ENSG00000178977 2 12346
ENSG00000089486 2 12301
ENSG00000213145 2 12165
ENSG00000085831 3 11826
ENSG00000206053 2 11819
ENSG00000135114 2 11815
ENSG00000120910 2 11675
ENSG00000183850 2 11635
ENSG00000162645 2 11614
ENSG00000168734 2 11380

All Genes

ENSG00000140511(18861), ENSG00000189013(18829), ENSG00000108700(18743), ENSG00000185885(17282), ENSG00000174885(15713), ENSG00000159618(15272), ENSG00000156265(14971), ENSG00000204642(14514), ENSG00000100918(13128), ENSG00000231389(12455), ENSG00000178977(12346), ENSG00000089486(12301), ENSG00000213145(12165), ENSG00000085831(11826), ENSG00000206053(11819), ENSG00000135114(11815), ENSG00000120910(11675), ENSG00000183850(11635), ENSG00000162645(11614), ENSG00000168734(11380), ENSG00000271503(11180), ENSG00000146618(11102), ENSG00000185880(10727), ENSG00000185933(10696), ENSG00000112039(10504), ENSG00000157404(10311), ENSG00000016082(10211), ENSG00000196735(10201), ENSG00000188282(10104), ENSG00000099399(10060), ENSG00000197251(10058), ENSG00000132744(9858), ENSG00000206337(9826), ENSG00000165182(9485), ENSG00000141437(9298), ENSG00000278540(9235), ENSG00000126458(9177), ENSG00000275763(8830), ENSG00000169507(8795), ENSG00000140853(8783), ENSG00000150991(8775), ENSG00000117148(8746), ENSG00000162063(8746), ENSG00000258653(8734), ENSG00000275302(8673), ENSG00000198502(8640), ENSG00000100911(8608), ENSG00000186891(8584), ENSG00000059378(8472), ENSG00000213578(8458), ENSG00000215012(8449), ENSG00000089127(8443), ENSG00000146858(8434), ENSG00000144460(8426), ENSG00000169249(8426), ENSG00000226025(8369), ENSG00000112062(8301), ENSG00000163631(8287), ENSG00000090339(8274), ENSG00000179344(8274), ENSG00000089692(8262), ENSG00000204287(8252), ENSG00000146648(8239), ENSG00000273136(8183), ENSG00000148386(8151), ENSG00000171180(8097), ENSG00000135355(8078), ENSG00000196126(8040), ENSG00000137267(7967), ENSG00000111801(7718), ENSG00000248385(7678), ENSG00000188906(7605), ENSG00000223865(7592), ENSG00000129472(7530), ENSG00000153563(7508), ENSG00000074181(7382), ENSG00000122304(7262), ENSG00000143469(7246), ENSG00000149781(7010), ENSG00000249948(6872), ENSG00000176083(6790), ENSG00000179583(6786), ENSG00000140534(6648), ENSG00000182986(6631), ENSG00000169953(6563), ENSG00000097096(6541), ENSG00000127616(6358), ENSG00000186150(6223), ENSG00000197536(6190), ENSG00000178927(6117), ENSG00000183559(6032), ENSG00000134321(5975), ENSG00000111640(5967), ENSG00000196081(5948), ENSG00000166710(5924), ENSG00000154438(5883), ENSG00000183155(5847), ENSG00000172671(5836), ENSG00000204257(5819), ENSG00000180616(5797), ENSG00000135446(5761), ENSG00000183795(5721), ENSG00000253276(5719), ENSG00000197122(5653), ENSG00000091831(5648), ENSG00000187608(5586), ENSG00000102743(5522), ENSG00000164270(5520), ENSG00000205978(5511), ENSG00000100300(5497), ENSG00000171105(5433), ENSG00000105617(5422), ENSG00000184471(5397), ENSG00000258818(5385), ENSG00000169248(5353), ENSG00000213886(5348), ENSG00000160803(5328), ENSG00000125363(5322), ENSG00000134153(5309), ENSG00000080824(5304), ENSG00000005249(5281), ENSG00000102178(5276), ENSG00000126785(5240), ENSG00000105357(5231), ENSG00000183795(5230), ENSG00000253831(5208), ENSG00000072062(5200), ENSG00000126803(5184), ENSG00000074800(5156), ENSG00000129682(5140), ENSG00000019582(5079), ENSG00000122728(5076), ENSG00000204252(5068), ENSG00000010295(5065), ENSG00000182866(5022), ENSG00000127418(4992), ENSG00000127472(4979), ENSG00000132698(4942), ENSG00000113721(4940), ENSG00000084774(4927), ENSG00000171345(4857), ENSG00000131203(4846), ENSG00000229474(4835), ENSG00000105374(4828), ENSG00000149806(4818), ENSG00000126583(4790), ENSG00000241106(4731), ENSG00000141510(4729), ENSG00000177989(4699), ENSG00000182749(4694), ENSG00000132170(4685), ENSG00000103356(4630), ENSG00000136003(4607), ENSG00000109193(4594), ENSG00000165782(4587), ENSG00000112139(4586), ENSG00000134253(4576), ENSG00000268107(4565), ENSG00000189377(4563), ENSG00000104140(4511), ENSG00000157884(4500), ENSG00000114491(4483), ENSG00000077080(4466), ENSG00000170325(4461), ENSG00000176894(4458), ENSG00000205835(4427), ENSG00000067560(4399), ENSG00000157600(4392), ENSG00000179796(4364), ENSG00000110975(4363), ENSG00000196684(4333), ENSG00000138413(4326), ENSG00000124256(4281), ENSG00000153790(4274), ENSG00000255432(4257), ENSG00000198515(4237), ENSG00000177606(4229), ENSG00000118473(4187), ENSG00000203499(4186), ENSG00000177143(4180), ENSG00000168036(4177), ENSG00000170312(4152), ENSG00000196335(4142), ENSG00000125347(4080), ENSG00000128342(4074), ENSG00000100030(4019), ENSG00000159899(3993), ENSG00000229205(3973), ENSG00000213215(3971), ENSG00000138613(3962), ENSG00000010810(3889), ENSG00000229676(3867), ENSG00000116455(3840), ENSG00000162595(3837), ENSG00000170476(3820), ENSG00000138613(3812), ENSG00000142089(3795), ENSG00000145936(3754), ENSG00000111335(3750), ENSG00000196358(3750), ENSG00000185379(3728), ENSG00000174446(3716), ENSG00000169515(3701), ENSG00000163632(3699), ENSG00000100302(3692), ENSG00000162654(3682), ENSG00000148156(3681), ENSG00000178035(3675), ENSG00000027644(3607), ENSG00000214087(3606), ENSG00000166415(3591), ENSG00000142208(3565), ENSG00000141736(3551), ENSG00000101457(3539), ENSG00000217442(3537), ENSG00000134684(3525), ENSG00000182050(3521), ENSG00000185933(3475), ENSG00000169906(3458), ENSG00000221963(3454), ENSG00000170315(3436), ENSG00000165584(3412), ENSG00000174775(3389), ENSG00000183421(3382), ENSG00000204371(3348), ENSG00000102882(3301), ENSG00000123201(3275), ENSG00000174899(3250), ENSG00000141668(3240), ENSG00000124226(3239), ENSG00000185585(3237), ENSG00000128891(3220), ENSG00000080503(3193), ENSG00000142621(3190), ENSG00000250317(3124), ENSG00000168925(3098), ENSG00000186458(3097), ENSG00000156575(3094), ENSG00000085831(3073), ENSG00000126752(3036), ENSG00000166710(3025), ENSG00000025423(3019), ENSG00000222038(3014), ENSG00000167244(3003), ENSG00000123374(2992), ENSG00000049247(2985), ENSG00000104325(2962), ENSG00000213886(2962), ENSG00000047578(2960), ENSG00000168925(2934), ENSG00000124721(2923), ENSG00000166523(2920), ENSG00000167077(2893), ENSG00000145936(2876), ENSG00000126790(2876), ENSG00000154928(2876), ENSG00000107758(2839), ENSG00000115085(2837), ENSG00000115073(2824), ENSG00000063180(2762), ENSG00000197587(2759), ENSG00000102178(2755), ENSG00000169245(2752), ENSG00000151883(2749), ENSG00000167011(2749), ENSG00000104833(2743), ENSG00000169750(2743), ENSG00000253313(2741), ENSG00000006451(2741), ENSG00000132915(2739), ENSG00000008853(2718), ENSG00000119917(2710), ENSG00000215386(2701), ENSG00000124782(2645), ENSG00000106436(2623), ENSG00000137842(2615), ENSG00000186603(2600), ENSG00000214274(2597), ENSG00000174697(2594), ENSG00000196834(2583), ENSG00000169248(2567), ENSG00000117266(2564), ENSG00000124227(2554), ENSG00000052795(2545), ENSG00000163121(2538), ENSG00000169507(2536), ENSG00000143632(2534), ENSG00000198668(2532), ENSG00000197891(2530), ENSG00000197272(2520), ENSG00000181847(2515), ENSG00000204116(2515), ENSG00000168268(2492), ENSG00000080824(2484), ENSG00000228741(2472), ENSG00000140368(2448), ENSG00000206072(2446), ENSG00000169717(2441), ENSG00000232629(2389), ENSG00000165949(2354), ENSG00000167476(2352), ENSG00000155366(2352), ENSG00000198793(2350), ENSG00000105976(2349), ENSG00000111206(2325), ENSG00000167183(2310), ENSG00000126785(2283), ENSG00000105357(2272), ENSG00000183785(2268), ENSG00000164885(2267), ENSG00000140463(2261), ENSG00000204928(2249), ENSG00000258989(2244), ENSG00000141510(2241), ENSG00000159251(2240), ENSG00000119922(2228), ENSG00000254505(2207), ENSG00000138755(2204), ENSG00000254647(2204), ENSG00000072133(2203), ENSG00000182583(2200), ENSG00000213967(2184), ENSG00000141437(2178), ENSG00000116663(2174), ENSG00000143185(2171), ENSG00000078487(2164), ENSG00000128383(2155), ENSG00000237787(2152), ENSG00000150676(2124), ENSG00000173626(2107), ENSG00000188130(2107), ENSG00000276644(2106), ENSG00000007264(2098), ENSG00000171105(2095), ENSG00000111335(2081), ENSG00000166833(2065), ENSG00000142102(2061), ENSG00000095794(2045), ENSG00000274180(2042), ENSG00000137496(2039), ENSG00000255330(2030), ENSG00000204006(2005), ENSG00000176490(2002), ENSG00000177504(1997), ENSG00000074966(1995), ENSG00000137959(1973), ENSG00000180745(1960), ENSG00000173401(1955), ENSG00000188389(1953), ENSG00000250550(1934), ENSG00000126583(1926), ENSG00000078142(1925), ENSG00000229674(1923), ENSG00000007171(1919), ENSG00000106571(1917), ENSG00000225526(1913), ENSG00000232810(1911), ENSG00000204290(1900), ENSG00000136048(1899), ENSG00000100342(1896), ENSG00000176040(1894), ENSG00000170345(1881), ENSG00000100422(1877), ENSG00000092096(1874), ENSG00000068400(1873), ENSG00000105370(1851), ENSG00000221953(1846), ENSG00000177508(1838), ENSG00000234745(1815), ENSG00000198520(1803), ENSG00000188612(1783), ENSG00000077080(1781), ENSG00000163293(1769), ENSG00000198678(1769), ENSG00000105329(1758), ENSG00000068985(1757), ENSG00000185262(1750), ENSG00000176635(1745), ENSG00000129559(1745), ENSG00000156284(1734), ENSG00000108551(1726), ENSG00000275778(1724), ENSG00000205916(1720), ENSG00000171729(1717), ENSG00000164867(1710), ENSG00000115523(1698), ENSG00000187553(1696), ENSG00000214050(1690), ENSG00000166828(1687), ENSG00000155875(1686), ENSG00000254692(1684), ENSG00000154451(1682), ENSG00000127472(1669), ENSG00000139572(1668), ENSG00000148602(1666), ENSG00000136238(1665), ENSG00000134398(1664), ENSG00000104129(1655), ENSG00000187483(1651), ENSG00000214140(1651), ENSG00000092820(1624), ENSG00000112592(1620), ENSG00000227868(1619), ENSG00000101421(1617), ENSG00000149809(1615), ENSG00000186470(1611), ENSG00000133256(1610), ENSG00000177673(1609), ENSG00000120217(1604), ENSG00000140564(1592), ENSG00000175505(1590), ENSG00000260092(1586), ENSG00000179219(1584), ENSG00000131966(1583), ENSG00000196712(1580), ENSG00000215343(1575), ENSG00000151327(1558), ENSG00000258311(1557), ENSG00000107249(1553), ENSG00000100139(1548), ENSG00000204779(1548), ENSG00000138685(1535), ENSG00000150456(1533), ENSG00000101082(1532), ENSG00000163909(1530), ENSG00000112186(1528), ENSG00000218336(1518), ENSG00000101266(1515), ENSG00000129514(1510), ENSG00000102096(1509), ENSG00000110711(1501), ENSG00000125826(1496), ENSG00000196182(1477), ENSG00000157613(1475), ENSG00000134250(1469), ENSG00000141194(1465), ENSG00000111537(1459), ENSG00000243749(1455), ENSG00000171219(1443), ENSG00000274020(1419), ENSG00000184351(1417), ENSG00000167123(1412), ENSG00000139083(1405), ENSG00000165731(1400), ENSG00000249581(1398), ENSG00000180616(1391), ENSG00000147647(1383), ENSG00000118513(1377), ENSG00000179930(1371), ENSG00000259399(1365), ENSG00000128335(1363), ENSG00000147262(1360), ENSG00000232859(1353), ENSG00000182795(1352), ENSG00000064270(1347), ENSG00000164742(1346), ENSG00000137824(1344), ENSG00000134539(1343), ENSG00000066468(1340), ENSG00000213714(1335), ENSG00000243130(1335), ENSG00000116981(1325), ENSG00000101017(1323), ENSG00000187003(1318), ENSG00000171552(1310), ENSG00000130477(1308), ENSG00000175520(1308), ENSG00000102385(1301), ENSG00000181355(1298), ENSG00000162039(1297), ENSG00000150457(1292), ENSG00000159131(1292), ENSG00000185386(1292), ENSG00000173421(1289), ENSG00000253831(1287), ENSG00000136997(1287), ENSG00000188191(1287), ENSG00000010219(1285), ENSG00000048052(1285), ENSG00000100453(1278), ENSG00000127951(1277), ENSG00000171180(1276), ENSG00000175550(1276), ENSG00000132141(1273), ENSG00000186765(1269), ENSG00000110987(1265), ENSG00000185028(1263), ENSG00000180999(1262), ENSG00000267041(1260), ENSG00000141736(1260), ENSG00000178021(1260), ENSG00000124587(1250), ENSG00000174938(1248), ENSG00000130675(1247), ENSG00000257127(1246), ENSG00000077782(1246), ENSG00000167553(1239), ENSG00000113721(1227), ENSG00000253958(1226), ENSG00000111331(1221), ENSG00000139656(1220), ENSG00000104783(1216), ENSG00000128408(1213), ENSG00000204592(1212), ENSG00000186827(1210), ENSG00000250506(1209), ENSG00000262576(1206), ENSG00000110195(1199), ENSG00000183258(1196), ENSG00000178950(1191), ENSG00000128203(1176), ENSG00000206069(1176), ENSG00000049769(1167), ENSG00000170315(1145), ENSG00000198947(1144), ENSG00000117228(1141), ENSG00000068305(1141), ENSG00000130635(1134), ENSG00000106976(1129), ENSG00000100031(1126), ENSG00000267710(1124), ENSG00000121690(1123), ENSG00000179388(1117), ENSG00000128789(1095), ENSG00000179958(1095), ENSG00000197915(1093), ENSG00000147481(1089), ENSG00000203784(1080), ENSG00000238269(1079), ENSG00000069431(1077), ENSG00000144354(1071), ENSG00000102755(1071), ENSG00000140612(1067), ENSG00000128394(1066), ENSG00000234409(1064), ENSG00000183054(1060), ENSG00000138669(1059), ENSG00000138669(1059), ENSG00000026950(1058), ENSG00000177084(1056), ENSG00000179348(1055), ENSG00000064201(1047), ENSG00000198794(1039), ENSG00000162976(1035), ENSG00000277481(1034), ENSG00000230510(1033), ENSG00000104518(1031), ENSG00000186496(1030), ENSG00000092010(1029), ENSG00000136869(1028), ENSG00000172543(1027), ENSG00000189143(1026), ENSG00000138496(1025), ENSG00000125975(1024), ENSG00000213928(1010), ENSG00000164270(1007), ENSG00000128045(1005), ENSG00000099999(1003), ENSG00000105221(1003), ENSG00000180090(1000), ENSG00000130528(995), ENSG00000104714(993), ENSG00000127249(990), ENSG00000234745(990), ENSG00000130723(987), ENSG00000178950(975), ENSG00000165182(973), ENSG00000154451(973), ENSG00000119403(969), ENSG00000126561(969), ENSG00000141448(969), ENSG00000196408(965), ENSG00000168404(960), ENSG00000232973(959), ENSG00000154358(956), ENSG00000167491(949), ENSG00000139899(948), ENSG00000099399(944), ENSG00000134853(939), ENSG00000104325(937), ENSG00000096968(937), ENSG00000174226(936), ENSG00000205352(935), ENSG00000118515(933), ENSG00000183248(931), ENSG00000280433(925), ENSG00000107175(922), ENSG00000176209(922), ENSG00000181873(914), ENSG00000118894(912), ENSG00000181409(904), ENSG00000176563(902), ENSG00000081760(901), ENSG00000175946(899), ENSG00000143891(895), ENSG00000165175(895), ENSG00000239920(891), ENSG00000198832(886), ENSG00000280670(885), ENSG00000136244(885), ENSG00000176095(884), ENSG00000185038(882), ENSG00000062485(867), ENSG00000180440(865), ENSG00000226023(863), ENSG00000010030(860), ENSG00000213793(860), ENSG00000146618(859), ENSG00000110042(854), ENSG00000133943(853), ENSG00000128191(850), ENSG00000102539(840), ENSG00000005339(836), ENSG00000161944(836), ENSG00000152214(836), ENSG00000267477(835), ENSG00000183629(829), ENSG00000148444(828), ENSG00000075673(826), ENSG00000150556(823), ENSG00000196422(823), ENSG00000215187(820), ENSG00000005022(816), ENSG00000213281(816), ENSG00000197233(813), ENSG00000132535(810), ENSG00000187653(808), ENSG00000186908(807), ENSG00000106541(805), ENSG00000168610(805), ENSG00000075624(800), ENSG00000196388(794), ENSG00000163958(791), ENSG00000171428(791), ENSG00000174939(790), ENSG00000139364(789), ENSG00000204525(788), ENSG00000163346(786), ENSG00000178568(784), ENSG00000226792(784), ENSG00000151577(781), ENSG00000128463(781), ENSG00000126456(775), ENSG00000181222(772), ENSG00000275896(772), ENSG00000184378(772), ENSG00000188219(771), ENSG00000185630(770), ENSG00000115073(770), ENSG00000181617(764), ENSG00000176387(763), ENSG00000181264(760), ENSG00000184560(755), ENSG00000196230(751), ENSG00000236334(750), ENSG00000157782(750), ENSG00000023839(747), ENSG00000196421(745), ENSG00000162595(745), ENSG00000156234(742), ENSG00000105220(741), ENSG00000130487(741), ENSG00000014914(740), ENSG00000168582(735), ENSG00000143199(734), ENSG00000120217(727), ENSG00000085840(726), ENSG00000196411(724), ENSG00000166851(720), ENSG00000128284(718), ENSG00000138031(717), ENSG00000197265(715), ENSG00000119401(712), ENSG00000156711(712), ENSG00000165233(710), ENSG00000178287(710), ENSG00000115112(706), ENSG00000198633(706), ENSG00000204700(705), ENSG00000001626(702), ENSG00000180644(702), ENSG00000121691(698), ENSG00000142748(697), ENSG00000243649(696), ENSG00000105519(694), ENSG00000152822(691), ENSG00000181798(687), ENSG00000103496(687), ENSG00000160908(686), ENSG00000186153(681), ENSG00000247626(677), ENSG00000173762(675), ENSG00000169067(671), ENSG00000126456(668), ENSG00000157765(666), ENSG00000163812(665), ENSG00000147457(663), ENSG00000196748(662), ENSG00000108511(661), ENSG00000164188(661), ENSG00000159723(659), ENSG00000172139(659), ENSG00000171217(658), ENSG00000257446(658), ENSG00000139160(657), ENSG00000204070(656), ENSG00000171116(653), ENSG00000251184(653), ENSG00000131097(651), ENSG00000137486(644), ENSG00000137501(641), ENSG00000279782(641), ENSG00000255302(640), ENSG00000157551(639), ENSG00000133687(638), ENSG00000176871(638), ENSG00000185888(636), ENSG00000134046(633), ENSG00000196240(630), ENSG00000008197(630), ENSG00000185532(629), ENSG00000239713(628), ENSG00000115274(626), ENSG00000134539(626), ENSG00000003989(625), ENSG00000071575(622), ENSG00000158480(620), ENSG00000204632(617), ENSG00000112877(616), ENSG00000243501(616), ENSG00000059758(615), ENSG00000198478(612), ENSG00000182168(610), ENSG00000101470(609), ENSG00000129460(608), ENSG00000140519(608), ENSG00000099139(608), ENSG00000133703(607), ENSG00000100206(603), ENSG00000102221(602), ENSG00000278463(602), ENSG00000272162(601), ENSG00000204315(601), ENSG00000145113(598), ENSG00000116478(598), ENSG00000196843(594), ENSG00000255524(592), ENSG00000118292(589), ENSG00000122643(589), ENSG00000198643(589), ENSG00000115592(589), ENSG00000005471(584), ENSG00000179058(584), ENSG00000167306(582), ENSG00000104388(581), ENSG00000148156(568), ENSG00000215883(564), ENSG00000055813(559), ENSG00000016402(558), ENSG00000168234(557), ENSG00000171793(556), ENSG00000196440(556), ENSG00000107731(555), ENSG00000157833(555), ENSG00000183185(555), ENSG00000164123(554), ENSG00000066230(553), ENSG00000177885(552), ENSG00000101470(551), ENSG00000135447(550), ENSG00000160752(550), ENSG00000167985(550), ENSG00000076248(549), ENSG00000181036(549), ENSG00000088320(546), ENSG00000181085(542), ENSG00000154319(539), ENSG00000103496(538), ENSG00000214866(536), ENSG00000100450(535), ENSG00000132471(535), ENSG00000112715(535), ENSG00000229571(535), ENSG00000115325(533), ENSG00000184611(533), ENSG00000196431(533), ENSG00000120322(532), ENSG00000162639(528), ENSG00000167588(527), ENSG00000198033(526), ENSG00000105963(524), ENSG00000165868(521), ENSG00000213999(518), ENSG00000196683(513), ENSG00000127585(512), ENSG00000019991(510), ENSG00000197016(510), ENSG00000150054(509), ENSG00000205089(508), ENSG00000183878(506), ENSG00000033327(505), ENSG00000129055(498), ENSG00000171722(498), ENSG00000100302(498), ENSG00000183166(498), ENSG00000135480(494), ENSG00000169436(493), ENSG00000213889(493), ENSG00000056487(492), ENSG00000196511(492), ENSG00000092853(491), ENSG00000184675(489), ENSG00000219435(484), ENSG00000185252(481), ENSG00000161544(480), ENSG00000043591(480), ENSG00000165643(478), ENSG00000134057(478), ENSG00000130813(476), ENSG00000173757(476), ENSG00000138823(473), ENSG00000154269(470), ENSG00000103522(470), ENSG00000164543(468), ENSG00000151150(467), ENSG00000167004(465), ENSG00000181786(465), ENSG00000181467(462), ENSG00000183864(461), ENSG00000157884(460), ENSG00000142279(459), ENSG00000168062(457), ENSG00000171862(456), ENSG00000271079(452), ENSG00000178445(452), ENSG00000177054(452), ENSG00000167531(449), ENSG00000134326(449), ENSG00000243772(448), ENSG00000177508(448), ENSG00000091513(448), ENSG00000054793(447), ENSG00000131153(447), ENSG00000185219(444), ENSG00000261678(444), ENSG00000100029(442), ENSG00000236279(441), ENSG00000085563(435), ENSG00000235750(434), ENSG00000011451(433), ENSG00000168928(433), ENSG00000236446(432), ENSG00000128340(431), ENSG00000021645(430), ENSG00000146910(430), ENSG00000184735(430), ENSG00000198157(430), ENSG00000256100(430), ENSG00000189431(429), ENSG00000164045(424), ENSG00000008083(423), ENSG00000188580(423), ENSG00000148400(421), ENSG00000176269(420), ENSG00000198700(418), ENSG00000104447(415), ENSG00000127663(415), ENSG00000185122(414), ENSG00000033170(413), ENSG00000092010(413), ENSG00000137513(412), ENSG00000225973(412), ENSG00000254706(410), ENSG00000259330(410), ENSG00000178965(409), ENSG00000114854(408), ENSG00000143569(407), ENSG00000253910(407), ENSG00000101109(406), ENSG00000240230(405), ENSG00000214872(403), ENSG00000114529(402), ENSG00000255561(401), ENSG00000141867(400), ENSG00000063438(399), ENSG00000132792(399), ENSG00000089012(398), ENSG00000110799(396), ENSG00000166527(396), ENSG00000101213(394), ENSG00000072274(393), ENSG00000175395(393), ENSG00000100985(393), ENSG00000108830(392), ENSG00000279956(388), ENSG00000081189(387), ENSG00000083814(386), ENSG00000212916(386), ENSG00000183844(385), ENSG00000189037(385), ENSG00000187821(383), ENSG00000159884(382), ENSG00000126709(381), ENSG00000172183(381), ENSG00000173821(380), ENSG00000281613(379), ENSG00000244020(378), ENSG00000006530(377), ENSG00000185475(377), ENSG00000101438(377), ENSG00000160193(377), ENSG00000126803(376), ENSG00000156381(375), ENSG00000130433(374), ENSG00000141946(374), ENSG00000139292(373), ENSG00000166913(372), ENSG00000186810(370), ENSG00000261210(369), ENSG00000184009(369), ENSG00000173077(368), ENSG00000081853(367), ENSG00000221957(366), ENSG00000103355(365), ENSG00000253649(365), ENSG00000183117(362), ENSG00000176165(362), ENSG00000167550(362), ENSG00000085999(361), ENSG00000163564(361), ENSG00000205057(361), ENSG00000087303(360), ENSG00000122035(355), ENSG00000138107(355), ENSG00000166484(355), ENSG00000137101(353), ENSG00000143674(352), ENSG00000117228(351), ENSG00000120332(350), ENSG00000196542(349), ENSG00000197046(349), ENSG00000124641(346), ENSG00000128655(346), ENSG00000091490(345), ENSG00000129250(345), ENSG00000166548(343), ENSG00000135052(342), ENSG00000158195(342), ENSG00000125166(342), ENSG00000013364(341), ENSG00000039068(341), ENSG00000012171(340), ENSG00000196981(340), ENSG00000109084(339), ENSG00000105499(337), ENSG00000147144(337), ENSG00000278705(337), ENSG00000186881(336), ENSG00000137571(335), ENSG00000104695(334), ENSG00000065320(333), ENSG00000153898(333), ENSG00000140464(333), ENSG00000113448(333), ENSG00000124762(332), ENSG00000137672(331), ENSG00000164171(331), ENSG00000005981(329), ENSG00000249860(329), ENSG00000138162(328), ENSG00000008853(328), ENSG00000168899(326), ENSG00000092377(325), ENSG00000117215(325), ENSG00000133398(325), ENSG00000171864(325), ENSG00000102225(324), ENSG00000095066(323), ENSG00000104365(323), ENSG00000168243(323), ENSG00000127955(322), ENSG00000132170(321), ENSG00000131747(321), ENSG00000185963(320), ENSG00000215910(320), ENSG00000243649(319), ENSG00000239306(319), ENSG00000214274(319), ENSG00000132821(316), ENSG00000153721(316), ENSG00000155287(315), ENSG00000237988(315), ENSG00000179142(315), ENSG00000258653(314), ENSG00000154153(313), ENSG00000094631(313), ENSG00000196081(312), ENSG00000076826(311), ENSG00000102387(311), ENSG00000164142(309), ENSG00000205220(309), ENSG00000122644(309), ENSG00000183117(307), ENSG00000172322(307), ENSG00000025423(307), ENSG00000100154(307), ENSG00000122145(306), ENSG00000144481(305), ENSG00000231023(305), ENSG00000135175(302), ENSG00000152661(301), ENSG00000267618(301), ENSG00000120738(300), ENSG00000162949(299), ENSG00000182584(298), ENSG00000124782(297), ENSG00000164292(297), ENSG00000139514(296), ENSG00000158773(295), ENSG00000229544(293), ENSG00000143839(293), ENSG00000103978(292), ENSG00000198001(292), ENSG00000187754(290), ENSG00000163959(289), ENSG00000181744(289), ENSG00000133321(286), ENSG00000204542(286), ENSG00000068079(285), ENSG00000227877(285), ENSG00000175634(284), ENSG00000100997(283), ENSG00000011052(283), ENSG00000102897(282), ENSG00000141452(282), ENSG00000254536(282), ENSG00000107796(282), ENSG00000132874(281), ENSG00000197951(281), ENSG00000230626(281), ENSG00000084764(281), ENSG00000097007(281), ENSG00000243978(279), ENSG00000261609(274), ENSG00000078295(274), ENSG00000103769(274), ENSG00000164308(273), ENSG00000171132(273), ENSG00000184984(272), ENSG00000110665(272), ENSG00000172468(271), ENSG00000180543(269), ENSG00000137462(269), ENSG00000135333(266), ENSG00000185201(265), ENSG00000277149(265), ENSG00000128052(265), ENSG00000122304(263), ENSG00000143653(263), ENSG00000187676(263), ENSG00000124772(261), ENSG00000159403(261), ENSG00000165131(260), ENSG00000185482(260), ENSG00000130158(258), ENSG00000214212(258), ENSG00000242019(258), ENSG00000155714(257), ENSG00000136305(254), ENSG00000099942(254), ENSG00000123416(253), ENSG00000174992(252), ENSG00000188334(252), ENSG00000226287(252), ENSG00000187905(252), ENSG00000140798(251), ENSG00000274588(250), ENSG00000170500(250), ENSG00000105825(249), ENSG00000213380(249), ENSG00000116574(248), ENSG00000278139(247), ENSG00000106789(243), ENSG00000099949(242), ENSG00000168802(242), ENSG00000051180(242), ENSG00000198211(242), ENSG00000204010(242), ENSG00000147408(240), ENSG00000188636(240), ENSG00000197506(240), ENSG00000072501(240), ENSG00000101945(240), ENSG00000008394(236), ENSG00000175077(236), ENSG00000188120(236), ENSG00000171791(236), ENSG00000080618(235), ENSG00000166603(234), ENSG00000232388(234), ENSG00000172602(233), ENSG00000102554(232), ENSG00000138639(232), ENSG00000166676(232), ENSG00000188641(232), ENSG00000137101(231), ENSG00000086300(231), ENSG00000205670(231), ENSG00000232838(231), ENSG00000079739(230), ENSG00000173110(230), ENSG00000188199(229), ENSG00000078725(228), ENSG00000166473(228), ENSG00000243667(228), ENSG00000244734(228), ENSG00000271793(228), ENSG00000124610(227), ENSG00000156194(227), ENSG00000134684(226), ENSG00000277586(225), ENSG00000267795(225), ENSG00000182035(222), ENSG00000134146(220), ENSG00000269035(220), ENSG00000112357(219), ENSG00000280778(219), ENSG00000105486(219), ENSG00000142949(217), ENSG00000160179(217), ENSG00000148719(217), ENSG00000109320(217), ENSG00000013374(217), ENSG00000165694(216), ENSG00000273167(216), ENSG00000081913(216), ENSG00000129873(216), ENSG00000212747(215), ENSG00000129521(215), ENSG00000243811(214), ENSG00000152760(213), ENSG00000243284(213), ENSG00000256500(212), ENSG00000136986(212), ENSG00000186448(210), ENSG00000101049(210), ENSG00000163209(209), ENSG00000174946(209), ENSG00000170390(207), ENSG00000168542(207), ENSG00000178229(205), ENSG00000171873(205), ENSG00000166106(204), ENSG00000105221(204), ENSG00000183831(204), ENSG00000196549(203), ENSG00000136810(203), ENSG00000103310(203), ENSG00000100906(202), ENSG00000155957(202), ENSG00000157111(202), ENSG00000277117(202), ENSG00000277494(202), ENSG00000261717(201), ENSG00000050130(200), ENSG00000114654(200), ENSG00000100604(200), ENSG00000130749(199), ENSG00000170935(199), ENSG00000130234(199), ENSG00000100823(199), ENSG00000101425(198), ENSG00000257335(197), ENSG00000134028(196), ENSG00000136297(196), ENSG00000101204(196), ENSG00000069956(196), ENSG00000124092(196), ENSG00000142149(195), ENSG00000124574(194), ENSG00000159263(194), ENSG00000110719(194), ENSG00000117139(193), ENSG00000104450(192), ENSG00000125378(192), ENSG00000163254(191), ENSG00000262655(191), ENSG00000224940(190), ENSG00000166090(189), ENSG00000216937(189), ENSG00000153201(189), ENSG00000175147(188), ENSG00000197889(188), ENSG00000129354(188), ENSG00000147099(188), ENSG00000181609(186), ENSG00000169660(186), ENSG00000131142(186), ENSG00000072422(186), ENSG00000204389(186), ENSG00000116455(184), ENSG00000151500(184), ENSG00000181929(184), ENSG00000212643(183), ENSG00000101439(183), ENSG00000016602(182), ENSG00000023902(182), ENSG00000136352(181), ENSG00000178690(179), ENSG00000078900(178), ENSG00000104660(178), ENSG00000128563(178), ENSG00000181396(178), ENSG00000114648(175), ENSG00000182606(175), ENSG00000223547(175), ENSG00000183979(174), ENSG00000205858(174), ENSG00000130762(172), ENSG00000100003(171), ENSG00000128610(171), ENSG00000147257(171), ENSG00000037280(171), ENSG00000215193(170), ENSG00000124217(170), ENSG00000165752(170), ENSG00000244242(169), ENSG00000137965(168), ENSG00000171877(168), ENSG00000229676(168), ENSG00000108771(168), ENSG00000167601(167), ENSG00000154229(167), ENSG00000159650(166), ENSG00000166669(166), ENSG00000189420(166), ENSG00000198807(165), ENSG00000163114(164), ENSG00000184923(164), ENSG00000075043(163), ENSG00000147459(163), ENSG00000171345(163), ENSG00000184110(163), ENSG00000105810(163), ENSG00000169026(162), ENSG00000117114(161), ENSG00000249693(161), ENSG00000152953(161), ENSG00000158186(161), ENSG00000153066(160), ENSG00000183628(160), ENSG00000116824(160), ENSG00000155380(160), ENSG00000116221(159), ENSG00000198429(159), ENSG00000214107(158), ENSG00000141040(158), ENSG00000130700(157), ENSG00000271321(157), ENSG00000169393(157), ENSG00000154928(156), ENSG00000082701(156), ENSG00000171388(155), ENSG00000102401(154), ENSG00000184588(154), ENSG00000128039(153), ENSG00000169344(153), ENSG00000066044(153), ENSG00000110092(153), ENSG00000163017(153), ENSG00000152778(152), ENSG00000229453(152), ENSG00000125952(151), ENSG00000137269(151), ENSG00000172772(151), ENSG00000275395(151), ENSG00000101353(150), ENSG00000126264(150), ENSG00000221949(150), ENSG00000037965(150), ENSG00000182957(150), ENSG00000136514(149), ENSG00000131871(149), ENSG00000105523(148), ENSG00000165029(148), ENSG00000115085(148), ENSG00000120725(148), ENSG00000076555(148), ENSG00000170606(147), ENSG00000176697(147), ENSG00000187682(147), ENSG00000181609(146), ENSG00000181698(146), ENSG00000204849(146), ENSG00000253313(146), ENSG00000172458(145), ENSG00000197587(145), ENSG00000177951(145), ENSG00000106012(144), ENSG00000171401(144), ENSG00000184992(144), ENSG00000198960(144), ENSG00000214128(144), ENSG00000106605(143), ENSG00000165152(143), ENSG00000185442(143), ENSG00000242574(143), ENSG00000104472(141), ENSG00000167925(141), ENSG00000172772(141), ENSG00000172752(140), ENSG00000140443(140), ENSG00000187957(139), ENSG00000114626(139), ENSG00000169609(138), ENSG00000137673(137), ENSG00000180042(137), ENSG00000127418(137), ENSG00000136161(136), ENSG00000188459(136), ENSG00000254709(136), ENSG00000110955(135), ENSG00000101017(135), ENSG00000101493(135), ENSG00000074842(134), ENSG00000139116(134), ENSG00000205542(134), ENSG00000198046(134), ENSG00000109906(134), ENSG00000150977(133), ENSG00000115685(133), ENSG00000017427(133), ENSG00000198691(132), ENSG00000108443(132), ENSG00000164924(132), ENSG00000140043(131), ENSG00000105835(131), ENSG00000160145(130), ENSG00000184898(130), ENSG00000205846(130), ENSG00000182070(130), ENSG00000137434(129), ENSG00000108688(129), ENSG00000108821(128), ENSG00000166848(128), ENSG00000231205(128), ENSG00000163932(128), ENSG00000239590(127), ENSG00000167633(127), ENSG00000175348(127), ENSG00000198019(127), ENSG00000102302(127), ENSG00000171316(127), ENSG00000197776(127), ENSG00000133083(127), ENSG00000255863(127), ENSG00000260851(127), ENSG00000165480(126), ENSG00000185915(126), ENSG00000189056(126), ENSG00000103275(126), ENSG00000147081(125), ENSG00000183476(125), ENSG00000237541(125), ENSG00000105204(125), ENSG00000111224(124), ENSG00000123165(124), ENSG00000118729(123), ENSG00000170477(123), ENSG00000239382(123), ENSG00000074219(123), ENSG00000162129(122), ENSG00000170653(122), ENSG00000180592(122), ENSG00000129559(122), ENSG00000139514(122), ENSG00000070831(122), ENSG00000100314(122), ENSG00000113734(121), ENSG00000165188(121), ENSG00000179284(121), ENSG00000185040(121), ENSG00000196872(121), ENSG00000080603(121), ENSG00000116212(120), ENSG00000173262(120), ENSG00000233757(120), ENSG00000196344(120), ENSG00000184216(119), ENSG00000108797(118), ENSG00000137274(118), ENSG00000204272(118), ENSG00000267041(118), ENSG00000123200(117), ENSG00000139112(117), ENSG00000152767(117), ENSG00000167618(117), ENSG00000072201(117), ENSG00000204366(117), ENSG00000168884(116), ENSG00000171014(116), ENSG00000079805(116), ENSG00000144791(115), ENSG00000142230(115), ENSG00000116133(114), ENSG00000166987(114), ENSG00000086570(114), ENSG00000187857(114), ENSG00000134308(114), ENSG00000175426(114), ENSG00000158683(113), ENSG00000168746(113), ENSG00000141574(113), ENSG00000104723(112), ENSG00000170128(112), ENSG00000172738(112), ENSG00000095794(112), ENSG00000181698(112), ENSG00000119650(112), ENSG00000139725(112), ENSG00000131059(111), ENSG00000263464(111), ENSG00000261456(110), ENSG00000169021(110), ENSG00000133627(110), ENSG00000173950(109), ENSG00000131408(109), ENSG00000028839(108), ENSG00000044524(108), ENSG00000125249(108), ENSG00000164032(108), ENSG00000186185(108), ENSG00000049247(107), ENSG00000175779(107), ENSG00000257062(107), ENSG00000069998(106), ENSG00000114248(106), ENSG00000162174(106), ENSG00000112096(106), ENSG00000178852(106), ENSG00000115520(105), ENSG00000149090(105), ENSG00000273079(105), ENSG00000181652(105), ENSG00000172717(104), ENSG00000204469(104), ENSG00000062485(104), ENSG00000125820(104), ENSG00000176842(104), ENSG00000010610(104), ENSG00000119703(103), ENSG00000128298(103), ENSG00000215717(103), ENSG00000106436(103), ENSG00000119401(103), ENSG00000185252(103), ENSG00000106588(103), ENSG00000173418(103), ENSG00000148408(102), ENSG00000073861(102), ENSG00000115963(102), ENSG00000137078(102), ENSG00000075702(101), ENSG00000088387(101), ENSG00000132297(101), ENSG00000214978(101), ENSG00000067066(100), ENSG00000139625(99), ENSG00000172324(99), ENSG00000116748(99), ENSG00000166394(99), ENSG00000133059(98), ENSG00000138744(98), ENSG00000143536(98), ENSG00000184564(98), ENSG00000024862(97), ENSG00000077984(97), ENSG00000140950(97), ENSG00000163568(97), ENSG00000171094(97), ENSG00000204815(97), ENSG00000184937(97), ENSG00000113520(96), ENSG00000168273(96), ENSG00000223573(96), ENSG00000221983(96), ENSG00000051523(95), ENSG00000259224(95), ENSG00000164086(95), ENSG00000135324(94), ENSG00000184260(94), ENSG00000184451(94), ENSG00000108797(94), ENSG00000166860(94), ENSG00000185507(94), ENSG00000182379(93), ENSG00000188375(93), ENSG00000268790(93), ENSG00000156564(93), ENSG00000205864(93), ENSG00000160117(92), ENSG00000180205(92), ENSG00000205542(92), ENSG00000070886(92), ENSG00000165702(92), ENSG00000264230(92), ENSG00000074803(91), ENSG00000114867(91), ENSG00000156219(91), ENSG00000166793(91), ENSG00000248746(91), ENSG00000138085(90), ENSG00000143032(90), ENSG00000145428(90), ENSG00000169964(90), ENSG00000188177(90), ENSG00000147647(90), ENSG00000148204(90), ENSG00000157005(90), ENSG00000129518(89), ENSG00000133636(89), ENSG00000141376(89), ENSG00000149499(89), ENSG00000172116(89), ENSG00000181007(89), ENSG00000198668(89), ENSG00000169032(89), ENSG00000175701(89), ENSG00000215560(89), ENSG00000180834(88), ENSG00000171552(88), ENSG00000165059(88), ENSG00000204482(88), ENSG00000090006(87), ENSG00000106819(87), ENSG00000115415(87), ENSG00000135245(87), ENSG00000174132(87), ENSG00000175513(87), ENSG00000178685(87), ENSG00000119636(86), ENSG00000143412(86), ENSG00000271741(86), ENSG00000198488(86), ENSG00000110888(85), ENSG00000117394(85), ENSG00000150656(85), ENSG00000182179(85), ENSG00000116095(84), ENSG00000125804(84), ENSG00000204301(84), ENSG00000069399(83), ENSG00000088899(83), ENSG00000108557(83), ENSG00000130119(83), ENSG00000204424(83), ENSG00000188056(82), ENSG00000255073(82), ENSG00000133059(82), ENSG00000111229(82), ENSG00000167286(82), ENSG00000092445(82), ENSG00000082684(81), ENSG00000147065(81), ENSG00000269711(81), ENSG00000144283(81), ENSG00000106397(80), ENSG00000113578(80), ENSG00000221888(80), ENSG00000221855(79), ENSG00000262526(79), ENSG00000180205(79), ENSG00000168938(79), ENSG00000197702(79), ENSG00000277058(79), ENSG00000038532(78), ENSG00000114770(78), ENSG00000152939(78), ENSG00000115306(78), ENSG00000244623(78), ENSG00000102466(77), ENSG00000161055(77), ENSG00000182107(77), ENSG00000157851(77), ENSG00000166123(77), ENSG00000169083(77), ENSG00000241973(77), ENSG00000120075(76), ENSG00000122679(76), ENSG00000162636(76), ENSG00000272196(76), ENSG00000141574(76), ENSG00000112658(76), ENSG00000118046(76), ENSG00000060491(75), ENSG00000126460(75), ENSG00000127415(75), ENSG00000253148(75), ENSG00000143171(75), ENSG00000164398(75), ENSG00000105610(75), ENSG00000173156(75), ENSG00000196260(75), ENSG00000007202(74), ENSG00000104671(74), ENSG00000130701(74), ENSG00000137080(74), ENSG00000152969(74), ENSG00000100276(74), ENSG00000167105(74), ENSG00000039600(73), ENSG00000105227(73), ENSG00000189320(73), ENSG00000203870(73), ENSG00000155506(73), ENSG00000181499(73), ENSG00000183734(73), ENSG00000113811(72), ENSG00000180447(72), ENSG00000204514(72), ENSG00000165584(72), ENSG00000125804(72), ENSG00000123610(72), ENSG00000102145(72), ENSG00000171720(72), ENSG00000261594(72), ENSG00000276043(72), ENSG00000080511(71), ENSG00000168283(71), ENSG00000184497(71), ENSG00000187531(71), ENSG00000143878(71), ENSG00000179761(70), ENSG00000187391(70), ENSG00000204713(70), ENSG00000273274(70), ENSG00000083307(70), ENSG00000115267(70), ENSG00000139734(70), ENSG00000168894(70), ENSG00000111087(70), ENSG00000267343(70), ENSG00000132475(69), ENSG00000139636(69), ENSG00000163491(69), ENSG00000082805(69), ENSG00000124571(69), ENSG00000117676(69), ENSG00000146904(69), ENSG00000061656(68), ENSG00000147535(68), ENSG00000186326(68), ENSG00000251359(68), ENSG00000273155(68), ENSG00000258989(68), ENSG00000182107(68), ENSG00000040531(67), ENSG00000164929(67), ENSG00000167964(67), ENSG00000187902(67), ENSG00000236882(67), ENSG00000196169(67), ENSG00000079689(67), ENSG00000106633(67), ENSG00000020577(67), ENSG00000125355(66), ENSG00000130023(66), ENSG00000161133(66), ENSG00000183036(66), ENSG00000188659(66), ENSG00000198221(66), ENSG00000221990(66), ENSG00000145649(66), ENSG00000156925(66), ENSG00000173273(66), ENSG00000126602(65), ENSG00000164778(65), ENSG00000177984(65), ENSG00000259417(65), ENSG00000004468(65), ENSG00000188171(65), ENSG00000221823(65), ENSG00000124243(64), ENSG00000142207(64), ENSG00000180801(64), ENSG00000254979(64), ENSG00000100906(64), ENSG00000102547(64), ENSG00000170892(63), ENSG00000184083(63), ENSG00000128191(63), ENSG00000162298(63), ENSG00000178921(63), ENSG00000071242(63), ENSG00000170608(63), ENSG00000074370(62), ENSG00000171772(62), ENSG00000176845(62), ENSG00000180089(62), ENSG00000157399(62), ENSG00000120156(62), ENSG00000185829(62), ENSG00000003989(61), ENSG00000112276(61), ENSG00000147155(61), ENSG00000148803(61), ENSG00000156966(61), ENSG00000198435(61), ENSG00000203690(61), ENSG00000104129(61), ENSG00000048462(61), ENSG00000174130(61), ENSG00000137764(61), ENSG00000117399(60), ENSG00000125046(60), ENSG00000125503(60), ENSG00000149043(60), ENSG00000159261(60), ENSG00000166313(60), ENSG00000182378(60), ENSG00000225899(60), ENSG00000205089(60), ENSG00000262526(60), ENSG00000108702(60), ENSG00000145335(60), ENSG00000018625(59), ENSG00000103888(59), ENSG00000137720(59), ENSG00000140264(59), ENSG00000147588(59), ENSG00000159733(59), ENSG00000188549(59), ENSG00000236882(59), ENSG00000130222(59), ENSG00000058091(59), ENSG00000162105(59), ENSG00000004478(58), ENSG00000054118(58), ENSG00000111863(58), ENSG00000125846(58), ENSG00000130720(58), ENSG00000134363(58), ENSG00000165671(58), ENSG00000166569(58), ENSG00000171763(58), ENSG00000198171(58), ENSG00000154237(58), ENSG00000181090(58), ENSG00000105426(58), ENSG00000169427(57), ENSG00000174945(57), ENSG00000205221(57), ENSG00000165502(57), ENSG00000269469(57), ENSG00000105668(56), ENSG00000117408(56), ENSG00000139880(56), ENSG00000160932(56), ENSG00000184148(56), ENSG00000249624(56), ENSG00000111404(56), ENSG00000132646(56), ENSG00000100299(55), ENSG00000113732(55), ENSG00000130940(55), ENSG00000133433(55), ENSG00000186075(55), ENSG00000189221(55), ENSG00000256349(55), ENSG00000270757(55), ENSG00000025434(55), ENSG00000125780(55), ENSG00000169635(55), ENSG00000125498(54), ENSG00000183763(54), ENSG00000187554(54), ENSG00000163812(54), ENSG00000172331(54), ENSG00000184205(54), ENSG00000172782(54), ENSG00000183807(54), ENSG00000105676(53), ENSG00000182199(53), ENSG00000079308(53), ENSG00000123143(53), ENSG00000163655(53), ENSG00000183891(53), ENSG00000187735(53), ENSG00000101342(53), ENSG00000114631(52), ENSG00000137261(52), ENSG00000154822(52), ENSG00000166762(52), ENSG00000005100(52), ENSG00000159450(52), ENSG00000163251(52), ENSG00000214357(52), ENSG00000127511(52), ENSG00000019102(52), ENSG00000084636(51), ENSG00000137726(51), ENSG00000153551(51), ENSG00000158457(51), ENSG00000169174(51), ENSG00000175482(51), ENSG00000184368(51), ENSG00000214087(51), ENSG00000124201(51), ENSG00000228198(51), ENSG00000149646(51), ENSG00000164070(51), ENSG00000106853(50), ENSG00000158553(50), ENSG00000167723(50), ENSG00000182853(50), ENSG00000187186(50), ENSG00000197128(50), ENSG00000229637(50), ENSG00000166828(50), ENSG00000196511(50), ENSG00000140319(50), ENSG00000185594(50), ENSG00000174130(49), ENSG00000005238(49), ENSG00000011590(49), ENSG00000103319(49), ENSG00000116117(49), ENSG00000137819(49), ENSG00000164756(49), ENSG00000169490(49), ENSG00000184319(49), ENSG00000274252(49), ENSG00000002549(49), ENSG00000147206(49), ENSG00000081842(49), ENSG00000267385(49), ENSG00000078814(48), ENSG00000115998(48), ENSG00000134864(48), ENSG00000152377(48), ENSG00000161021(48), ENSG00000161180(48), ENSG00000171246(48), ENSG00000176619(48), ENSG00000184454(48), ENSG00000237988(48), ENSG00000092421(48), ENSG00000111319(48), ENSG00000181045(48), ENSG00000085382(48), ENSG00000163349(48), ENSG00000167094(48), ENSG00000179941(48), ENSG00000187862(48), ENSG00000139405(48), ENSG00000011105(47), ENSG00000110237(47), ENSG00000121361(47), ENSG00000123999(47), ENSG00000124508(47), ENSG00000182600(47), ENSG00000205863(47), ENSG00000019991(47), ENSG00000114302(47), ENSG00000168214(47), ENSG00000123171(47), ENSG00000090447(46), ENSG00000163704(46), ENSG00000186103(46), ENSG00000171793(46), ENSG00000225899(46), ENSG00000011485(46), ENSG00000075218(45), ENSG00000103381(45), ENSG00000104221(45), ENSG00000154518(45), ENSG00000163536(45), ENSG00000164649(45), ENSG00000167747(45), ENSG00000168958(45), ENSG00000178093(45), ENSG00000184887(45), ENSG00000115998(45), ENSG00000163083(45), ENSG00000177108(45), ENSG00000136574(45), ENSG00000163914(45), ENSG00000205867(45), ENSG00000106410(44), ENSG00000112511(44), ENSG00000136932(44), ENSG00000175175(44), ENSG00000185090(44), ENSG00000196639(44), ENSG00000198885(44), ENSG00000221986(44), ENSG00000233041(44), ENSG00000105220(44), ENSG00000148773(44), ENSG00000168071(44), ENSG00000118432(44), ENSG00000144118(44), ENSG00000249967(44), ENSG00000070269(44), ENSG00000204709(44), ENSG00000133872(43), ENSG00000188996(43), ENSG00000189144(43), ENSG00000244476(43), ENSG00000197233(43), ENSG00000185482(43), ENSG00000132466(43), ENSG00000145555(43), ENSG00000173020(43), ENSG00000131473(43), ENSG00000168269(43), ENSG00000177189(43), ENSG00000246922(43), ENSG00000105202(42), ENSG00000133606(42), ENSG00000135617(42), ENSG00000203837(42), ENSG00000164692(42), ENSG00000175518(42), ENSG00000182185(42), ENSG00000273269(42), ENSG00000278522(42), ENSG00000179994(41), ENSG00000181374(41), ENSG00000196507(41), ENSG00000197208(41), ENSG00000213996(41), ENSG00000276231(41), ENSG00000127124(41), ENSG00000177084(41), ENSG00000082482(41), ENSG00000101255(41), ENSG00000138814(41), ENSG00000172137(41), ENSG00000212122(41), ENSG00000253626(41), ENSG00000256825(41), ENSG00000048471(40), ENSG00000126953(40), ENSG00000137878(40), ENSG00000183779(40), ENSG00000160219(40), ENSG00000215386(40), ENSG00000085840(40), ENSG00000104856(40), ENSG00000130948(40), ENSG00000138135(40), ENSG00000162009(40), ENSG00000189058(40), ENSG00000025772(40), ENSG00000142627(40), ENSG00000188229(40), ENSG00000196972(40), ENSG00000181045(39), ENSG00000121898(39), ENSG00000135148(39), ENSG00000150477(39), ENSG00000157734(39), ENSG00000158089(39), ENSG00000184933(39), ENSG00000187416(39), ENSG00000275074(39), ENSG00000133106(39), ENSG00000109193(39), ENSG00000112511(39), ENSG00000149489(39), ENSG00000162772(39), ENSG00000117154(39), ENSG00000142961(39), ENSG00000185499(39), ENSG00000273769(39), ENSG00000100483(38), ENSG00000112559(38), ENSG00000113648(38), ENSG00000154102(38), ENSG00000180881(38), ENSG00000143891(38), ENSG00000095596(38), ENSG00000176720(38), ENSG00000179915(38), ENSG00000070770(38), ENSG00000049768(37), ENSG00000125850(37), ENSG00000172292(37), ENSG00000197965(37), ENSG00000197980(37), ENSG00000131979(37), ENSG00000143851(37), ENSG00000156958(37), ENSG00000185338(37), ENSG00000163435(37), ENSG00000166592(37), ENSG00000187658(37), ENSG00000212789(37), ENSG00000274559(37), ENSG00000137462(36), ENSG00000121851(36), ENSG00000127419(36), ENSG00000178409(36), ENSG00000196263(36), ENSG00000254553(36), ENSG00000254636(36), ENSG00000269096(36), ENSG00000100483(36), ENSG00000145604(36), ENSG00000156304(36), ENSG00000105048(36), ENSG00000129152(36), ENSG00000143947(36), ENSG00000162552(36), ENSG00000198125(36), ENSG00000155256(36), ENSG00000164849(36), ENSG00000137747(35), ENSG00000167969(35), ENSG00000215113(35), ENSG00000033327(35), ENSG00000168062(35), ENSG00000125851(35), ENSG00000143622(35), ENSG00000150753(35), ENSG00000178776(35), ENSG00000086696(34), ENSG00000101417(34), ENSG00000134247(34), ENSG00000162545(34), ENSG00000172932(34), ENSG00000179178(34), ENSG00000179468(34), ENSG00000181562(34), ENSG00000203778(34), ENSG00000213853(34), ENSG00000234289(34), ENSG00000105963(34), ENSG00000069399(34), ENSG00000137133(34), ENSG00000143184(34), ENSG00000162396(34), ENSG00000133818(34), ENSG00000164690(34), ENSG00000172086(34), ENSG00000183674(34), ENSG00000259956(34), ENSG00000086730(34), ENSG00000127324(33), ENSG00000132274(33), ENSG00000149635(33), ENSG00000168913(33), ENSG00000171914(33), ENSG00000175727(33), ENSG00000117480(33), ENSG00000143178(33), ENSG00000121769(32), ENSG00000171053(32), ENSG00000175463(32), ENSG00000274750(32), ENSG00000275714(32), ENSG00000185630(32), ENSG00000164045(32), ENSG00000172292(32), ENSG00000104267(32), ENSG00000129007(32), ENSG00000135624(32), ENSG00000141639(32), ENSG00000162434(32), ENSG00000185615(32), ENSG00000143001(32), ENSG00000064300(31), ENSG00000102287(31), ENSG00000112655(31), ENSG00000132128(31), ENSG00000134690(31), ENSG00000160886(31), ENSG00000167774(31), ENSG00000171004(31), ENSG00000223820(31), ENSG00000248546(31), ENSG00000076248(31), ENSG00000156269(31), ENSG00000167741(31), ENSG00000103710(31), ENSG00000108179(31), ENSG00000139668(31), ENSG00000113621(31), ENSG00000134830(31), ENSG00000180878(31), ENSG00000185905(31), ENSG00000068650(30), ENSG00000100564(30), ENSG00000104825(30), ENSG00000110723(30), ENSG00000153060(30), ENSG00000155428(30), ENSG00000155542(30), ENSG00000161267(30), ENSG00000176393(30), ENSG00000213923(30), ENSG00000196182(30), ENSG00000078081(30), ENSG00000143067(30), ENSG00000155368(30), ENSG00000101057(30), ENSG00000135838(30), ENSG00000155111(30), ENSG00000175352(30), ENSG00000131389(30), ENSG00000157502(30), ENSG00000183798(30), ENSG00000050393(29), ENSG00000072832(29), ENSG00000085185(29), ENSG00000100426(29), ENSG00000104805(29), ENSG00000115289(29), ENSG00000165548(29), ENSG00000167653(29), ENSG00000177842(29), ENSG00000184389(29), ENSG00000196460(29), ENSG00000204128(29), ENSG00000229715(29), ENSG00000235608(29), ENSG00000228741(29), ENSG00000007264(29), ENSG00000197980(29), ENSG00000146678(29), ENSG00000243156(29), ENSG00000065328(29), ENSG00000103550(29), ENSG00000147145(29), ENSG00000169668(29), ENSG00000078081(28), ENSG00000011332(28), ENSG00000099822(28), ENSG00000166847(28), ENSG00000185069(28), ENSG00000197622(28), ENSG00000258713(28), ENSG00000183559(28), ENSG00000248546(28), ENSG00000008018(28), ENSG00000137337(28), ENSG00000143476(28), ENSG00000163508(28), ENSG00000171786(28), ENSG00000130561(28), ENSG00000143643(28), ENSG00000171574(28), ENSG00000185345(28), ENSG00000185896(28), ENSG00000127993(28), ENSG00000248993(28), ENSG00000268655(28), ENSG00000121716(27), ENSG00000164007(27), ENSG00000166289(27), ENSG00000196517(27), ENSG00000176393(27), ENSG00000229715(27), ENSG00000016490(27), ENSG00000065183(27), ENSG00000132109(27), ENSG00000029559(27), ENSG00000116106(27), ENSG00000267216(27), ENSG00000110218(26), ENSG00000134940(26), ENSG00000159289(26), ENSG00000173801(26), ENSG00000228570(26), ENSG00000104833(26), ENSG00000213967(26), ENSG00000169436(26), ENSG00000137513(26), ENSG00000127324(26), ENSG00000121769(26), ENSG00000087510(26), ENSG00000134812(26), ENSG00000172289(26), ENSG00000103222(26), ENSG00000104321(26), ENSG00000108946(26), ENSG00000130203(26), ENSG00000178947(26), ENSG00000189057(26), ENSG00000204548(26), ENSG00000269891(26), ENSG00000272822(26), ENSG00000273398(26), ENSG00000068654(25), ENSG00000125510(25), ENSG00000146205(25), ENSG00000162836(25), ENSG00000181963(25), ENSG00000198825(25), ENSG00000258986(25), ENSG00000177143(25), ENSG00000127124(25), ENSG00000103342(25), ENSG00000135472(25), ENSG00000140632(25), ENSG00000172348(25), ENSG00000183715(25), ENSG00000134287(25), ENSG00000163468(25), ENSG00000168421(25), ENSG00000150337(25), ENSG00000160593(25), ENSG00000168917(25), ENSG00000188916(25), ENSG00000212724(25), ENSG00000259916(25), ENSG00000089327(24), ENSG00000128283(24), ENSG00000154654(24), ENSG00000188729(24), ENSG00000253846(24), ENSG00000261308(24), ENSG00000279983(24), ENSG00000188305(24), ENSG00000213999(24), ENSG00000156381(24), ENSG00000216937(24), ENSG00000113262(24), ENSG00000147655(24), ENSG00000180902(24), ENSG00000128833(24), ENSG00000175793(24), ENSG00000182580(24), ENSG00000166317(24), ENSG00000184599(24), ENSG00000011523(23), ENSG00000060138(23), ENSG00000070614(23), ENSG00000109339(23), ENSG00000119242(23), ENSG00000134780(23), ENSG00000134873(23), ENSG00000157927(23), ENSG00000161281(23), ENSG00000177225(23), ENSG00000183346(23), ENSG00000187742(23), ENSG00000196381(23), ENSG00000204822(23), ENSG00000215126(23), ENSG00000257127(23), ENSG00000138075(23), ENSG00000179409(23), ENSG00000074266(23), ENSG00000104213(23), ENSG00000113558(23), ENSG00000146592(23), ENSG00000160447(23), ENSG00000181092(23), ENSG00000136828(23), ENSG00000165816(23), ENSG00000275464(23), ENSG00000179144(23), ENSG00000033122(22), ENSG00000090554(22), ENSG00000099954(22), ENSG00000125734(22), ENSG00000182934(22), ENSG00000197273(22), ENSG00000221968(22), ENSG00000167244(22), ENSG00000100422(22), ENSG00000151577(22), ENSG00000101294(22), ENSG00000117586(22), ENSG00000132465(22), ENSG00000166136(22), ENSG00000171759(22), ENSG00000172215(22), ENSG00000138395(22), ENSG00000141314(22), ENSG00000163517(22), ENSG00000203666(22), ENSG00000171489(22), ENSG00000177992(22), ENSG00000260300(22), ENSG00000268041(22), ENSG00000176635(21), ENSG00000105738(21), ENSG00000111424(21), ENSG00000132879(21), ENSG00000142694(21), ENSG00000148704(21), ENSG00000186212(21), ENSG00000188050(21), ENSG00000188596(21), ENSG00000239887(21), ENSG00000271949(21), ENSG00000159899(21), ENSG00000153898(21), ENSG00000196517(21), ENSG00000096996(21), ENSG00000139645(21), ENSG00000044574(21), ENSG00000102010(21), ENSG00000124228(21), ENSG00000159399(21), ENSG00000184900(21), ENSG00000267261(21), ENSG00000268643(21), ENSG00000101447(21), ENSG00000164385(21), ENSG00000168398(21), ENSG00000152684(20), ENSG00000179409(20), ENSG00000065621(20), ENSG00000069020(20), ENSG00000119913(20), ENSG00000143093(20), ENSG00000187624(20), ENSG00000196655(20), ENSG00000128408(20), ENSG00000138823(20), ENSG00000155957(20), ENSG00000075790(20), ENSG00000103274(20), ENSG00000105612(20), ENSG00000124422(20), ENSG00000143093(20), ENSG00000146918(20), ENSG00000167971(20), ENSG00000168418(20), ENSG00000175203(20), ENSG00000249459(20), ENSG00000037474(20), ENSG00000077264(20), ENSG00000186462(20), ENSG00000197535(20), ENSG00000177294(20), ENSG00000232070(20), ENSG00000116661(19), ENSG00000125821(19), ENSG00000129219(19), ENSG00000130818(19), ENSG00000135413(19), ENSG00000136379(19), ENSG00000148057(19), ENSG00000163933(19), ENSG00000167565(19), ENSG00000184635(19), ENSG00000186051(19), ENSG00000198939(19), ENSG00000187037(19), ENSG00000183185(19), ENSG00000243772(19), ENSG00000198019(19), ENSG00000109339(19), ENSG00000090554(19), ENSG00000158526(19), ENSG00000196724(19), ENSG00000068078(19), ENSG00000080815(19), ENSG00000102978(19), ENSG00000196296(19), ENSG00000099869(19), ENSG00000113555(19), ENSG00000215274(19), ENSG00000276203(19), ENSG00000276397(19), ENSG00000100312(18), ENSG00000100926(18), ENSG00000125430(18), ENSG00000146707(18), ENSG00000159763(18), ENSG00000167767(18), ENSG00000172530(18), ENSG00000180357(18), ENSG00000181751(18), ENSG00000181355(18), ENSG00000133398(18), ENSG00000152969(18), ENSG00000279983(18), ENSG00000060138(18), ENSG00000025708(18), ENSG00000119938(18), ENSG00000160182(18), ENSG00000169194(18), ENSG00000181408(18), ENSG00000187764(18), ENSG00000105639(18), ENSG00000113916(18), ENSG00000188386(18), ENSG00000172568(18), ENSG00000187984(18), ENSG00000204687(18), ENSG00000074527(17), ENSG00000136160(17), ENSG00000136295(17), ENSG00000142794(17), ENSG00000163378(17), ENSG00000164199(17), ENSG00000174788(17), ENSG00000180537(17), ENSG00000184185(17), ENSG00000196476(17), ENSG00000242515(17), ENSG00000100031(17), ENSG00000011451(17), ENSG00000004478(17), ENSG00000188305(17), ENSG00000187624(17), ENSG00000004660(17), ENSG00000071539(17), ENSG00000102871(17), ENSG00000112038(17), ENSG00000138002(17), ENSG00000146828(17), ENSG00000168306(17), ENSG00000266953(17), ENSG00000106683(17), ENSG00000115850(17), ENSG00000125863(17), ENSG00000127314(17), ENSG00000228927(17), ENSG00000123243(17), ENSG00000187005(17), ENSG00000205476(17), ENSG00000229549(17), ENSG00000248329(17), ENSG00000248485(17), ENSG00000278057(17), ENSG00000105655(16), ENSG00000123892(16), ENSG00000143502(16), ENSG00000148482(16), ENSG00000161057(16), ENSG00000166997(16), ENSG00000173320(16), ENSG00000186889(16), ENSG00000269190(16), ENSG00000269586(16), ENSG00000189143(16), ENSG00000175395(16), ENSG00000177225(16), ENSG00000125844(16), ENSG00000139410(16), ENSG00000164087(16), ENSG00000167110(16), ENSG00000172053(16), ENSG00000178358(16), ENSG00000180787(16), ENSG00000198911(16), ENSG00000053372(16), ENSG00000065978(16), ENSG00000079112(16), ENSG00000087258(16), ENSG00000109971(16), ENSG00000130522(16), ENSG00000135605(16), ENSG00000147596(16), ENSG00000158716(16), ENSG00000166949(16), ENSG00000186951(16), ENSG00000136811(16), ENSG00000141579(16), ENSG00000163357(16), ENSG00000164008(16), ENSG00000187616(16), ENSG00000255874(16), ENSG00000152684(15), ENSG00000040731(15), ENSG00000072954(15), ENSG00000100065(15), ENSG00000100836(15), ENSG00000100938(15), ENSG00000113742(15), ENSG00000127362(15), ENSG00000129103(15), ENSG00000134259(15), ENSG00000135519(15), ENSG00000136159(15), ENSG00000136197(15), ENSG00000165169(15), ENSG00000167614(15), ENSG00000175137(15), ENSG00000177689(15), ENSG00000185404(15), ENSG00000198546(15), ENSG00000234469(15), ENSG00000261857(15), ENSG00000274070(15), ENSG00000105352(15), ENSG00000213793(15), ENSG00000184185(15), ENSG00000122705(15), ENSG00000160712(15), ENSG00000160799(15), ENSG00000168872(15), ENSG00000088930(15), ENSG00000113812(15), ENSG00000132881(15), ENSG00000134533(15), ENSG00000139144(15), ENSG00000160191(15), ENSG00000177432(15), ENSG00000179456(15), ENSG00000185960(15), ENSG00000077279(15), ENSG00000109944(15), ENSG00000133619(15), ENSG00000255439(15), ENSG00000263201(15), ENSG00000105369(14), ENSG00000120896(14), ENSG00000130173(14), ENSG00000131653(14), ENSG00000144893(14), ENSG00000149488(14), ENSG00000158234(14), ENSG00000163069(14), ENSG00000166450(14), ENSG00000173918(14), ENSG00000173930(14), ENSG00000174137(14), ENSG00000181215(14), ENSG00000186970(14), ENSG00000196074(14), ENSG00000249581(14), ENSG00000147144(14), ENSG00000182035(14), ENSG00000133106(14), ENSG00000094661(14), ENSG00000103375(14), ENSG00000105829(14), ENSG00000138279(14), ENSG00000148082(14), ENSG00000166401(14), ENSG00000196433(14), ENSG00000197472(14), ENSG00000221910(14), ENSG00000258659(14), ENSG00000128951(14), ENSG00000160321(14), ENSG00000162086(14), ENSG00000162924(14), ENSG00000182521(14), ENSG00000204390(14), ENSG00000126705(14), ENSG00000155254(14), ENSG00000176402(14), ENSG00000264058(14), ENSG00000270882(14), ENSG00000113205(13), ENSG00000116830(13), ENSG00000119862(13), ENSG00000126246(13), ENSG00000162139(13), ENSG00000163449(13), ENSG00000165072(13), ENSG00000167543(13), ENSG00000168334(13), ENSG00000176485(13), ENSG00000177374(13), ENSG00000178531(13), ENSG00000197448(13), ENSG00000204175(13), ENSG00000129514(13), ENSG00000213380(13), ENSG00000138744(13), ENSG00000274070(13), ENSG00000049089(13), ENSG00000100288(13), ENSG00000105568(13), ENSG00000112984(13), ENSG00000127129(13), ENSG00000129474(13), ENSG00000171596(13), ENSG00000172057(13), ENSG00000172362(13), ENSG00000178531(13), ENSG00000198589(13), ENSG00000206418(13), ENSG00000113575(13), ENSG00000114166(13), ENSG00000126088(13), ENSG00000155980(13), ENSG00000101898(13), ENSG00000102055(13), ENSG00000160298(13), ENSG00000162522(13), ENSG00000164743(13), ENSG00000173213(13), ENSG00000188610(13), ENSG00000196436(13), ENSG00000204869(13), ENSG00000256436(13), ENSG00000086758(12), ENSG00000090861(12), ENSG00000092871(12), ENSG00000099991(12), ENSG00000105516(12), ENSG00000116685(12), ENSG00000135378(12), ENSG00000135749(12), ENSG00000137976(12), ENSG00000140379(12), ENSG00000143850(12), ENSG00000151014(12), ENSG00000157637(12), ENSG00000168517(12), ENSG00000170262(12), ENSG00000181577(12), ENSG00000183671(12), ENSG00000185176(12), ENSG00000185862(12), ENSG00000204540(12), ENSG00000255275(12), ENSG00000268182(12), ENSG00000198515(12), ENSG00000275778(12), ENSG00000137501(12), ENSG00000261609(12), ENSG00000023902(12), ENSG00000271321(12), ENSG00000163449(12), ENSG00000065060(12), ENSG00000102265(12), ENSG00000112578(12), ENSG00000130766(12), ENSG00000136068(12), ENSG00000169962(12), ENSG00000170890(12), ENSG00000173473(12), ENSG00000198601(12), ENSG00000237649(12), ENSG00000240682(12), ENSG00000066056(12), ENSG00000127334(12), ENSG00000144134(12), ENSG00000145242(12), ENSG00000157456(12), ENSG00000161681(12), ENSG00000177453(12), ENSG00000183454(12), ENSG00000185236(12), ENSG00000106302(12), ENSG00000150527(12), ENSG00000165006(12), ENSG00000166946(12), ENSG00000237524(12), ENSG00000257315(12), ENSG00000275663(12), ENSG00000276430(12), ENSG00000264058(11), ENSG00000007933(11), ENSG00000041982(11), ENSG00000083544(11), ENSG00000142449(11), ENSG00000146574(11), ENSG00000149633(11), ENSG00000176087(11), ENSG00000182508(11), ENSG00000185745(11), ENSG00000187699(11), ENSG00000196787(11), ENSG00000256950(11), ENSG00000137310(11), ENSG00000154822(11), ENSG00000064195(11), ENSG00000088298(11), ENSG00000140263(11), ENSG00000142973(11), ENSG00000151729(11), ENSG00000152192(11), ENSG00000184160(11), ENSG00000204264(11), ENSG00000257341(11), ENSG00000006071(11), ENSG00000096384(11), ENSG00000105507(11), ENSG00000113966(11), ENSG00000116473(11), ENSG00000130589(11), ENSG00000136628(11), ENSG00000139890(11), ENSG00000153208(11), ENSG00000153266(11), ENSG00000159921(11), ENSG00000163501(11), ENSG00000099812(11), ENSG00000116691(11), ENSG00000126749(11), ENSG00000143614(11), ENSG00000160963(11), ENSG00000179314(11), ENSG00000180096(11), ENSG00000220948(11), ENSG00000251287(11), ENSG00000269955(11), ENSG00000276581(11), ENSG00000278259(11), ENSG00000104738(10), ENSG00000104827(10), ENSG00000108666(10), ENSG00000131149(10), ENSG00000134369(10), ENSG00000145103(10), ENSG00000145386(10), ENSG00000159184(10), ENSG00000176381(10), ENSG00000176746(10), ENSG00000186862(10), ENSG00000187135(10), ENSG00000187527(10), ENSG00000221883(10), ENSG00000227729(10), ENSG00000267552(10), ENSG00000168925(10), ENSG00000215883(10), ENSG00000197016(10), ENSG00000259330(10), ENSG00000205057(10), ENSG00000105499(10), ENSG00000111224(10), ENSG00000137274(10), ENSG00000276231(10), ENSG00000129103(10), ENSG00000116830(10), ENSG00000084754(10), ENSG00000092969(10), ENSG00000101849(10), ENSG00000103671(10), ENSG00000103740(10), ENSG00000110031(10), ENSG00000115935(10), ENSG00000125814(10), ENSG00000131844(10), ENSG00000147383(10), ENSG00000149016(10), ENSG00000163359(10), ENSG00000167720(10), ENSG00000053918(10), ENSG00000089250(10), ENSG00000113389(10), ENSG00000114861(10), ENSG00000120694(10), ENSG00000102125(10), ENSG00000103852(10), ENSG00000104691(10), ENSG00000131943(10), ENSG00000135451(10), ENSG00000138606(10), ENSG00000153531(10), ENSG00000159761(10), ENSG00000164197(10), ENSG00000180083(10), ENSG00000196313(10), ENSG00000197991(10), ENSG00000219545(10), ENSG00000225932(10), ENSG00000238105(10), ENSG00000250719(10), ENSG00000265118(10), ENSG00000269791(10), ENSG00000273313(10), ENSG00000278570(10), ENSG00000008283(9), ENSG00000083817(9), ENSG00000100298(9), ENSG00000107745(9), ENSG00000119547(9), ENSG00000128564(9), ENSG00000151726(9), ENSG00000159164(9), ENSG00000162373(9), ENSG00000165512(9), ENSG00000166546(9), ENSG00000174473(9), ENSG00000182362(9), ENSG00000204963(9), ENSG00000239395(9), ENSG00000177409(9), ENSG00000123201(9), ENSG00000156575(9), ENSG00000149809(9), ENSG00000023839(9), ENSG00000154269(9), ENSG00000089154(9), ENSG00000102962(9), ENSG00000104951(9), ENSG00000105447(9), ENSG00000108405(9), ENSG00000109255(9), ENSG00000110400(9), ENSG00000115705(9), ENSG00000129351(9), ENSG00000135476(9), ENSG00000141642(9), ENSG00000154127(9), ENSG00000158874(9), ENSG00000164136(9), ENSG00000172534(9), ENSG00000178381(9), ENSG00000197540(9), ENSG00000198010(9), ENSG00000206172(9), ENSG00000269547(9), ENSG00000004846(9), ENSG00000105397(9), ENSG00000130653(9), ENSG00000155304(9), ENSG00000166140(9), ENSG00000172680(9), ENSG00000187109(9), ENSG00000105889(9), ENSG00000115207(9), ENSG00000136485(9), ENSG00000140832(9), ENSG00000146859(9), ENSG00000154781(9), ENSG00000168070(9), ENSG00000183463(9), ENSG00000204237(9), ENSG00000206262(9), ENSG00000234776(9), ENSG00000255408(9), ENSG00000267080(9), ENSG00000271810(9), ENSG00000023171(8), ENSG00000086288(8), ENSG00000089723(8), ENSG00000104613(8), ENSG00000108381(8), ENSG00000130147(8), ENSG00000132259(8), ENSG00000133983(8), ENSG00000134779(8), ENSG00000139737(8), ENSG00000147439(8), ENSG00000160200(8), ENSG00000161594(8), ENSG00000169306(8), ENSG00000171195(8), ENSG00000175602(8), ENSG00000185753(8), ENSG00000197153(8), ENSG00000197712(8), ENSG00000213965(8), ENSG00000117226(8), ENSG00000179796(8), ENSG00000259399(8), ENSG00000137486(8), ENSG00000160752(8), ENSG00000164543(8), ENSG00000185475(8), ENSG00000135052(8), ENSG00000187754(8), ENSG00000106789(8), ENSG00000142949(8), ENSG00000237541(8), ENSG00000184497(8), ENSG00000105352(8), ENSG00000185176(8), ENSG00000137310(8), ENSG00000187527(8), ENSG00000107745(8), ENSG00000078808(8), ENSG00000086548(8), ENSG00000100600(8), ENSG00000102384(8), ENSG00000112699(8), ENSG00000114739(8), ENSG00000124222(8), ENSG00000129988(8), ENSG00000136267(8), ENSG00000143409(8), ENSG00000143473(8), ENSG00000145934(8), ENSG00000156928(8), ENSG00000158717(8), ENSG00000160469(8), ENSG00000164129(8), ENSG00000170734(8), ENSG00000173166(8), ENSG00000189060(8), ENSG00000060140(8), ENSG00000079974(8), ENSG00000086717(8), ENSG00000088876(8), ENSG00000108840(8), ENSG00000115138(8), ENSG00000117118(8), ENSG00000134594(8), ENSG00000137494(8), ENSG00000147050(8), ENSG00000156510(8), ENSG00000166869(8), ENSG00000177595(8), ENSG00000183943(8), ENSG00000196591(8), ENSG00000215372(8), ENSG00000075399(8), ENSG00000085552(8), ENSG00000104415(8), ENSG00000112787(8), ENSG00000160401(8), ENSG00000160953(8), ENSG00000162981(8), ENSG00000168792(8), ENSG00000170909(8), ENSG00000177558(8), ENSG00000179071(8), ENSG00000182459(8), ENSG00000197309(8), ENSG00000224982(8), ENSG00000240021(8), ENSG00000243775(8), ENSG00000258529(8), ENSG00000263513(8), ENSG00000263639(8), ENSG00000265808(8), ENSG00000269855(8), ENSG00000278637(8), ENSG00000042832(7), ENSG00000073331(7), ENSG00000103023(7), ENSG00000103067(7), ENSG00000105392(7), ENSG00000108018(7), ENSG00000117477(7), ENSG00000140682(7), ENSG00000163071(7), ENSG00000170516(7), ENSG00000180229(7), ENSG00000197753(7), ENSG00000254852(7), ENSG00000225526(7), ENSG00000101421(7), ENSG00000260092(7), ENSG00000277481(7), ENSG00000104714(7), ENSG00000180440(7), ENSG00000131153(7), ENSG00000168802(7), ENSG00000110955(7), ENSG00000113578(7), ENSG00000011590(7), ENSG00000068650(7), ENSG00000137976(7), ENSG00000151014(7), ENSG00000221883(7), ENSG00000239395(7), ENSG00000090889(7), ENSG00000103197(7), ENSG00000105514(7), ENSG00000118655(7), ENSG00000124194(7), ENSG00000124766(7), ENSG00000135913(7), ENSG00000148218(7), ENSG00000166206(7), ENSG00000168079(7), ENSG00000168878(7), ENSG00000171700(7), ENSG00000173212(7), ENSG00000182704(7), ENSG00000187498(7), ENSG00000197362(7), ENSG00000213171(7), ENSG00000008118(7), ENSG00000111674(7), ENSG00000122025(7), ENSG00000142784(7), ENSG00000148053(7), ENSG00000174437(7), ENSG00000175592(7), ENSG00000180815(7), ENSG00000186716(7), ENSG00000198682(7), ENSG00000120669(7), ENSG00000121289(7), ENSG00000121381(7), ENSG00000129932(7), ENSG00000147041(7), ENSG00000167131(7), ENSG00000167281(7), ENSG00000177494(7), ENSG00000188011(7), ENSG00000188015(7), ENSG00000188112(7), ENSG00000188981(7), ENSG00000204060(7), ENSG00000205301(7), ENSG00000212124(7), ENSG00000215712(7), ENSG00000239779(7), ENSG00000240403(7), ENSG00000274049(7), ENSG00000031081(6), ENSG00000073754(6), ENSG00000092200(6), ENSG00000094804(6), ENSG00000104228(6), ENSG00000104331(6), ENSG00000104998(6), ENSG00000106305(6), ENSG00000106608(6), ENSG00000107679(6), ENSG00000108465(6), ENSG00000111879(6), ENSG00000133466(6), ENSG00000134802(6), ENSG00000137700(6), ENSG00000147799(6), ENSG00000158483(6), ENSG00000160679(6), ENSG00000169059(6), ENSG00000170627(6), ENSG00000172159(6), ENSG00000175718(6), ENSG00000182108(6), ENSG00000196505(6), ENSG00000204682(6), ENSG00000213445(6), ENSG00000213462(6), ENSG00000213988(6), ENSG00000253159(6), ENSG00000260456(6), ENSG00000274736(6), ENSG00000182050(6), ENSG00000141668(6), ENSG00000197915(6), ENSG00000239920(6), ENSG00000085563(6), ENSG00000117139(6), ENSG00000100003(6), ENSG00000185442(6), ENSG00000187699(6), ENSG00000145386(6), ENSG00000187135(6), ENSG00000119547(6), ENSG00000204963(6), ENSG00000007923(6), ENSG00000065923(6), ENSG00000066084(6), ENSG00000083457(6), ENSG00000085644(6), ENSG00000092330(6), ENSG00000103495(6), ENSG00000105323(6), ENSG00000113645(6), ENSG00000114200(6), ENSG00000119139(6), ENSG00000120341(6), ENSG00000125398(6), ENSG00000125815(6), ENSG00000130055(6), ENSG00000137806(6), ENSG00000141086(6), ENSG00000143603(6), ENSG00000155846(6), ENSG00000158517(6), ENSG00000169297(6), ENSG00000170310(6), ENSG00000170509(6), ENSG00000170954(6), ENSG00000173113(6), ENSG00000175215(6), ENSG00000177807(6), ENSG00000178252(6), ENSG00000185046(6), ENSG00000203663(6), ENSG00000248098(6), ENSG00000065361(6), ENSG00000070759(6), ENSG00000076201(6), ENSG00000084072(6), ENSG00000117020(6), ENSG00000125845(6), ENSG00000128245(6), ENSG00000133475(6), ENSG00000134070(6), ENSG00000142875(6), ENSG00000155897(6), ENSG00000166598(6), ENSG00000169429(6), ENSG00000182541(6), ENSG00000183317(6), ENSG00000184895(6), ENSG00000185624(6), ENSG00000198225(6), ENSG00000198355(6), ENSG00000205213(6), ENSG00000267318(6), ENSG00000107829(6), ENSG00000113583(6), ENSG00000119698(6), ENSG00000134569(6), ENSG00000136816(6), ENSG00000147676(6), ENSG00000154114(6), ENSG00000163009(6), ENSG00000167566(6), ENSG00000168348(6), ENSG00000175676(6), ENSG00000188493(6), ENSG00000197006(6), ENSG00000197253(6), ENSG00000224960(6), ENSG00000242441(6), ENSG00000250510(6), ENSG00000251297(6), ENSG00000256977(6), ENSG00000257065(6), ENSG00000257921(6), ENSG00000259120(6), ENSG00000271858(6), ENSG00000273706(6), ENSG00000276950(6), ENSG00000277632(6), ENSG00000281348(6), ENSG00000167984(6), ENSG00000041353(5), ENSG00000105429(5), ENSG00000112293(5), ENSG00000113758(5), ENSG00000116273(5), ENSG00000130052(5), ENSG00000133020(5), ENSG00000135902(5), ENSG00000157657(5), ENSG00000161013(5), ENSG00000161298(5), ENSG00000162068(5), ENSG00000162747(5), ENSG00000167065(5), ENSG00000174827(5), ENSG00000186136(5), ENSG00000198216(5), ENSG00000205754(5), ENSG00000229894(5), ENSG00000265818(5), ENSG00000106560(5), ENSG00000111729(5), ENSG00000047578(5), ENSG00000182583(5), ENSG00000150456(5), ENSG00000125975(5), ENSG00000081760(5), ENSG00000150556(5), ENSG00000185219(5), ENSG00000158195(5), ENSG00000197951(5), ENSG00000153066(5), ENSG00000221949(5), ENSG00000239382(5), ENSG00000119703(5), ENSG00000187037(5), ENSG00000181215(5), ENSG00000007968(5), ENSG00000021762(5), ENSG00000038427(5), ENSG00000056558(5), ENSG00000104419(5), ENSG00000105429(5), ENSG00000112183(5), ENSG00000123240(5), ENSG00000126003(5), ENSG00000128050(5), ENSG00000128271(5), ENSG00000129991(5), ENSG00000138101(5), ENSG00000139684(5), ENSG00000148848(5), ENSG00000161849(5), ENSG00000162892(5), ENSG00000166908(5), ENSG00000170581(5), ENSG00000170961(5), ENSG00000177489(5), ENSG00000180879(5), ENSG00000186230(5), ENSG00000196352(5), ENSG00000197653(5), ENSG00000197822(5), ENSG00000198805(5), ENSG00000198929(5), ENSG00000203757(5), ENSG00000248099(5), ENSG00000021826(5), ENSG00000058668(5), ENSG00000092345(5), ENSG00000107937(5), ENSG00000114062(5), ENSG00000118271(5), ENSG00000119729(5), ENSG00000125965(5), ENSG00000135018(5), ENSG00000136866(5), ENSG00000145908(5), ENSG00000148606(5), ENSG00000152556(5), ENSG00000163110(5), ENSG00000166526(5), ENSG00000166825(5), ENSG00000170950(5), ENSG00000170967(5), ENSG00000172352(5), ENSG00000172977(5), ENSG00000183770(5), ENSG00000186976(5), ENSG00000106560(5), ENSG00000109680(5), ENSG00000120055(5), ENSG00000135763(5), ENSG00000139178(5), ENSG00000151287(5), ENSG00000151376(5), ENSG00000151838(5), ENSG00000156282(5), ENSG00000171224(5), ENSG00000174950(5), ENSG00000176182(5), ENSG00000188167(5), ENSG00000188883(5), ENSG00000189186(5), ENSG00000196228(5), ENSG00000197457(5), ENSG00000215472(5), ENSG00000243317(5), ENSG00000274211(5), ENSG00000050344(5), ENSG00000054219(5), ENSG00000271605(5), ENSG00000003249(4), ENSG00000011132(4), ENSG00000037757(4), ENSG00000040608(4), ENSG00000084710(4), ENSG00000089091(4), ENSG00000100053(4), ENSG00000111696(4), ENSG00000118804(4), ENSG00000125148(4), ENSG00000125875(4), ENSG00000127561(4), ENSG00000131435(4), ENSG00000132635(4), ENSG00000136261(4), ENSG00000136867(4), ENSG00000137338(4), ENSG00000139192(4), ENSG00000139344(4), ENSG00000144559(4), ENSG00000149547(4), ENSG00000152092(4), ENSG00000153904(4), ENSG00000160991(4), ENSG00000162512(4), ENSG00000165509(4), ENSG00000167272(4), ENSG00000168026(4), ENSG00000171824(4), ENSG00000174165(4), ENSG00000175643(4), ENSG00000176783(4), ENSG00000177047(4), ENSG00000177943(4), ENSG00000182013(4), ENSG00000183496(4), ENSG00000186174(4), ENSG00000186814(4), ENSG00000187122(4), ENSG00000197948(4), ENSG00000198889(4), ENSG00000275832(4), ENSG00000184471(4), ENSG00000167011(4), ENSG00000204928(4), ENSG00000148602(4), ENSG00000186496(4), ENSG00000236334(4), ENSG00000197265(4), ENSG00000198033(4), ENSG00000130158(4), ENSG00000178229(4), ENSG00000277494(4), ENSG00000171388(4), ENSG00000239590(4), ENSG00000115415(4), ENSG00000178685(4), ENSG00000271741(4), ENSG00000130023(4), ENSG00000163536(4), ENSG00000160219(4), ENSG00000112655(4), ENSG00000185404(4), ENSG00000117477(4), ENSG00000254852(4), ENSG00000031081(4), ENSG00000073754(4), ENSG00000137700(4), ENSG00000175718(4), ENSG00000260456(4), ENSG00000011021(4), ENSG00000064601(4), ENSG00000070495(4), ENSG00000077150(4), ENSG00000085978(4), ENSG00000088247(4), ENSG00000091010(4), ENSG00000094755(4), ENSG00000100949(4), ENSG00000105254(4), ENSG00000108691(4), ENSG00000111716(4), ENSG00000118804(4), ENSG00000119655(4), ENSG00000120899(4), ENSG00000122678(4), ENSG00000123146(4), ENSG00000130827(4), ENSG00000132932(4), ENSG00000134905(4), ENSG00000137166(4), ENSG00000141434(4), ENSG00000143631(4), ENSG00000145545(4), ENSG00000152782(4), ENSG00000152932(4), ENSG00000156414(4), ENSG00000156709(4), ENSG00000158169(4), ENSG00000158571(4), ENSG00000160602(4), ENSG00000162702(4), ENSG00000165898(4), ENSG00000167434(4), ENSG00000167578(4), ENSG00000168710(4), ENSG00000168781(4), ENSG00000169733(4), ENSG00000170289(4), ENSG00000170689(4), ENSG00000172803(4), ENSG00000178235(4), ENSG00000179151(4), ENSG00000181523(4), ENSG00000183386(4), ENSG00000183579(4), ENSG00000185760(4), ENSG00000186350(4), ENSG00000186352(4), ENSG00000189091(4), ENSG00000198131(4), ENSG00000198855(4), ENSG00000204634(4), ENSG00000214013(4), ENSG00000215853(4), ENSG00000219073(4), ENSG00000015568(4), ENSG00000032444(4), ENSG00000055130(4), ENSG00000087245(4), ENSG00000088992(4), ENSG00000091436(4), ENSG00000099956(4), ENSG00000101890(4), ENSG00000105679(4), ENSG00000106526(4), ENSG00000106615(4), ENSG00000108953(4), ENSG00000109819(4), ENSG00000115091(4), ENSG00000115414(4), ENSG00000122877(4), ENSG00000125508(4), ENSG00000128881(4), ENSG00000133101(4), ENSG00000138738(4), ENSG00000142330(4), ENSG00000143322(4), ENSG00000143933(4), ENSG00000145362(4), ENSG00000149294(4), ENSG00000154342(4), ENSG00000160014(4), ENSG00000163795(4), ENSG00000164916(4), ENSG00000165023(4), ENSG00000167580(4), ENSG00000167658(4), ENSG00000168078(4), ENSG00000178607(4), ENSG00000183475(4), ENSG00000185304(4), ENSG00000186310(4), ENSG00000196363(4), ENSG00000196503(4), ENSG00000205944(4), ENSG00000000003(4), ENSG00000006534(4), ENSG00000047662(4), ENSG00000048740(4), ENSG00000069188(4), ENSG00000101158(4), ENSG00000104881(4), ENSG00000105341(4), ENSG00000105711(4), ENSG00000111412(4), ENSG00000121350(4), ENSG00000122574(4), ENSG00000125827(4), ENSG00000126337(4), ENSG00000131188(4), ENSG00000135736(4), ENSG00000141316(4), ENSG00000141664(4), ENSG00000143061(4), ENSG00000144648(4), ENSG00000146049(4), ENSG00000149925(4), ENSG00000149932(4), ENSG00000158477(4), ENSG00000158806(4), ENSG00000163001(4), ENSG00000163040(4), ENSG00000163689(4), ENSG00000163701(4), ENSG00000164663(4), ENSG00000165164(4), ENSG00000165821(4), ENSG00000166578(4), ENSG00000169807(4), ENSG00000170044(4), ENSG00000173065(4), ENSG00000175728(4), ENSG00000179082(4), ENSG00000182165(4), ENSG00000182397(4), ENSG00000183695(4), ENSG00000185187(4), ENSG00000185900(4), ENSG00000186818(4), ENSG00000186897(4), ENSG00000188032(4), ENSG00000188511(4), ENSG00000196976(4), ENSG00000196993(4), ENSG00000197479(4), ENSG00000204882(4), ENSG00000205236(4), ENSG00000205707(4), ENSG00000205710(4), ENSG00000206077(4), ENSG00000214324(4), ENSG00000227507(4), ENSG00000228836(4), ENSG00000244094(4), ENSG00000253537(4), ENSG00000255823(4), ENSG00000261732(4), ENSG00000263528(4), ENSG00000265690(4), ENSG00000266265(4), ENSG00000272047(4), ENSG00000272398(4), ENSG00000272414(4), ENSG00000274419(4), ENSG00000279012(4), ENSG00000101363(3), ENSG00000112280(3), ENSG00000115008(3), ENSG00000121314(3), ENSG00000128683(3), ENSG00000149557(3), ENSG00000186090(3), ENSG00000213512(3), ENSG00000150676(3), ENSG00000204006(3), ENSG00000141194(3), ENSG00000110195(3), ENSG00000206069(3), ENSG00000267710(3), ENSG00000196408(3), ENSG00000279782(3), ENSG00000138162(3), ENSG00000141452(3), ENSG00000254536(3), ENSG00000138639(3), ENSG00000166676(3), ENSG00000160179(3), ENSG00000114654(3), ENSG00000142149(3), ENSG00000262655(3), ENSG00000175147(3), ENSG00000125952(3), ENSG00000165029(3), ENSG00000254709(3), ENSG00000167633(3), ENSG00000233757(3), ENSG00000171094(3), ENSG00000051523(3), ENSG00000188375(3), ENSG00000147535(3), ENSG00000142207(3), ENSG00000182199(3), ENSG00000196507(3), ENSG00000157734(3), ENSG00000275074(3), ENSG00000125430(3), ENSG00000092871(3), ENSG00000100298(3), ENSG00000157657(3), ENSG00000229894(3), ENSG00000049246(3), ENSG00000065357(3), ENSG00000075415(3), ENSG00000095319(3), ENSG00000099810(3), ENSG00000100121(3), ENSG00000100209(3), ENSG00000100567(3), ENSG00000101441(3), ENSG00000102034(3), ENSG00000103642(3), ENSG00000105662(3), ENSG00000108309(3), ENSG00000108823(3), ENSG00000111780(3), ENSG00000121064(3), ENSG00000121380(3), ENSG00000131409(3), ENSG00000134138(3), ENSG00000140474(3), ENSG00000158258(3), ENSG00000159459(3), ENSG00000162975(3), ENSG00000163599(3), ENSG00000164068(3), ENSG00000168135(3), ENSG00000174586(3), ENSG00000176410(3), ENSG00000177469(3), ENSG00000186487(3), ENSG00000186635(3), ENSG00000204021(3), ENSG00000204843(3), ENSG00000216490(3), ENSG00000243135(3), ENSG00000068024(3), ENSG00000077327(3), ENSG00000100697(3), ENSG00000107968(3), ENSG00000132510(3), ENSG00000141655(3), ENSG00000142192(3), ENSG00000150672(3), ENSG00000160973(3), ENSG00000166743(3), ENSG00000167791(3), ENSG00000173334(3), ENSG00000173366(3), ENSG00000174282(3), ENSG00000176974(3), ENSG00000184492(3), ENSG00000185988(3), ENSG00000186868(3), ENSG00000187446(3), ENSG00000198028(3), ENSG00000230031(3), ENSG00000258992(3), ENSG00000065989(3), ENSG00000087302(3), ENSG00000104112(3), ENSG00000121236(3), ENSG00000127423(3), ENSG00000143393(3), ENSG00000147255(3), ENSG00000157570(3), ENSG00000158764(3), ENSG00000164002(3), ENSG00000165490(3), ENSG00000165511(3), ENSG00000165899(3), ENSG00000166262(3), ENSG00000169499(3), ENSG00000169789(3), ENSG00000169989(3), ENSG00000172250(3), ENSG00000175820(3), ENSG00000177191(3), ENSG00000182077(3), ENSG00000204661(3), ENSG00000213240(3), ENSG00000222009(3), ENSG00000226430(3), ENSG00000231560(3), ENSG00000235162(3), ENSG00000267467(3), ENSG00000268104(3), ENSG00000268916(3), ENSG00000268975(3), ENSG00000274933(3), ENSG00000275342(3), ENSG00000121594(3), ENSG00000145088(3), ENSG00000240065(3), ENSG00000164483(3), ENSG00000087157(2), ENSG00000102924(2), ENSG00000109743(2), ENSG00000120784(2), ENSG00000130643(2), ENSG00000132010(2), ENSG00000136213(2), ENSG00000143158(2), ENSG00000164932(2), ENSG00000176919(2), ENSG00000179820(2), ENSG00000182346(2), ENSG00000183826(2), ENSG00000197430(2), ENSG00000198542(2), ENSG00000243207(2), ENSG00000008324(2), ENSG00000137098(2), ENSG00000183833(2), ENSG00000125363(2), ENSG00000268107(2), ENSG00000198678(2), ENSG00000205916(2), ENSG00000116981(2), ENSG00000130477(2), ENSG00000102385(2), ENSG00000069431(2), ENSG00000181409(2), ENSG00000275896(2), ENSG00000181264(2), ENSG00000108511(2), ENSG00000257446(2), ENSG00000204632(2), ENSG00000167985(2), ENSG00000271079(2), ENSG00000054793(2), ENSG00000006530(2), ENSG00000183117(2), ENSG00000005981(2), ENSG00000215910(2), ENSG00000153721(2), ENSG00000172322(2), ENSG00000152661(2), ENSG00000229544(2), ENSG00000230626(2), ENSG00000185201(2), ENSG00000105825(2), ENSG00000205670(2), ENSG00000050130(2), ENSG00000117114(2), ENSG00000166848(2), ENSG00000165480(2), ENSG00000185915(2), ENSG00000123200(2), ENSG00000170128(2), ENSG00000069998(2), ENSG00000128298(2), ENSG00000160117(2), ENSG00000139636(2), ENSG00000061656(2), ENSG00000198435(2), ENSG00000134363(2), ENSG00000187186(2), ENSG00000090447(2), ENSG00000164649(2), ENSG00000049768(2), ENSG00000100426(2), ENSG00000162836(2), ENSG00000011523(2), ENSG00000185862(2), ENSG00000083817(2), ENSG00000265818(2), ENSG00000111729(2), ENSG00000136867(2), ENSG00000112280(2), ENSG00000149557(2), ENSG00000186090(2), ENSG00000001561(2), ENSG00000002745(2), ENSG00000004939(2), ENSG00000010292(2), ENSG00000011198(2), ENSG00000011304(2), ENSG00000021461(2), ENSG00000022840(2), ENSG00000036473(2), ENSG00000038002(2), ENSG00000049860(2), ENSG00000051596(2), ENSG00000070366(2), ENSG00000073350(2), ENSG00000075290(2), ENSG00000076864(2), ENSG00000077235(2), ENSG00000079313(2), ENSG00000080031(2), ENSG00000087077(2), ENSG00000087085(2), ENSG00000088827(2), ENSG00000090530(2), ENSG00000091129(2), ENSG00000091164(2), ENSG00000092531(2), ENSG00000100227(2), ENSG00000100867(2), ENSG00000102970(2), ENSG00000103490(2), ENSG00000103549(2), ENSG00000103942(2), ENSG00000104826(2), ENSG00000104946(2), ENSG00000105173(2), ENSG00000105281(2), ENSG00000105737(2), ENSG00000106245(2), ENSG00000106992(2), ENSG00000107077(2), ENSG00000107242(2), ENSG00000109743(2), ENSG00000110244(2), ENSG00000110852(2), ENSG00000112685(2), ENSG00000114125(2), ENSG00000114316(2), ENSG00000114487(2), ENSG00000114646(2), ENSG00000114812(2), ENSG00000115221(2), ENSG00000115425(2), ENSG00000115657(2), ENSG00000116147(2), ENSG00000116809(2), ENSG00000124469(2), ENSG00000124479(2), ENSG00000128805(2), ENSG00000129187(2), ENSG00000129667(2), ENSG00000130226(2), ENSG00000130724(2), ENSG00000131368(2), ENSG00000131373(2), ENSG00000131788(2), ENSG00000131845(2), ENSG00000133661(2), ENSG00000133816(2), ENSG00000134258(2), ENSG00000134716(2), ENSG00000134899(2), ENSG00000135002(2), ENSG00000135423(2), ENSG00000135454(2), ENSG00000136108(2), ENSG00000136213(2), ENSG00000137561(2), ENSG00000137628(2), ENSG00000138166(2), ENSG00000138356(2), ENSG00000138622(2), ENSG00000138623(2), ENSG00000139193(2), ENSG00000139644(2), ENSG00000140057(2), ENSG00000140876(2), ENSG00000140986(2), ENSG00000141084(2), ENSG00000141098(2), ENSG00000143147(2), ENSG00000143179(2), ENSG00000143387(2), ENSG00000144045(2), ENSG00000144285(2), ENSG00000144554(2), ENSG00000144645(2), ENSG00000145020(2), ENSG00000145331(2), ENSG00000145414(2), ENSG00000145888(2), ENSG00000146007(2), ENSG00000146072(2), ENSG00000147044(2), ENSG00000147140(2), ENSG00000147416(2), ENSG00000147533(2), ENSG00000147586(2), ENSG00000149133(2), ENSG00000149136(2), ENSG00000153093(2), ENSG00000153707(2), ENSG00000153982(2), ENSG00000154027(2), ENSG00000157601(2), ENSG00000158578(2), ENSG00000159200(2), ENSG00000159387(2), ENSG00000159556(2), ENSG00000159840(2), ENSG00000160460(2), ENSG00000161798(2), ENSG00000162191(2), ENSG00000162881(2), ENSG00000162896(2), ENSG00000163362(2), ENSG00000163930(2), ENSG00000164604(2), ENSG00000164707(2), ENSG00000164935(2), ENSG00000166197(2), ENSG00000166508(2), ENSG00000166794(2), ENSG00000167604(2), ENSG00000167978(2), ENSG00000167986(2), ENSG00000168002(2), ENSG00000168394(2), ENSG00000168397(2), ENSG00000168763(2), ENSG00000169213(2), ENSG00000169255(2), ENSG00000169777(2), ENSG00000171649(2), ENSG00000171794(2), ENSG00000172014(2), ENSG00000172216(2), ENSG00000173826(2), ENSG00000173991(2), ENSG00000174611(2), ENSG00000175143(2), ENSG00000177602(2), ENSG00000177666(2), ENSG00000179134(2), ENSG00000180198(2), ENSG00000180806(2), ENSG00000181191(2), ENSG00000181513(2), ENSG00000182326(2), ENSG00000184209(2), ENSG00000184307(2), ENSG00000184381(2), ENSG00000184922(2), ENSG00000185608(2), ENSG00000185650(2), ENSG00000186866(2), ENSG00000187021(2), ENSG00000188536(2), ENSG00000188542(2), ENSG00000196072(2), ENSG00000196184(2), ENSG00000196345(2), ENSG00000197226(2), ENSG00000197586(2), ENSG00000197635(2), ENSG00000198445(2), ENSG00000198835(2), ENSG00000204392(2), ENSG00000204519(2), ENSG00000204842(2), ENSG00000204967(2), ENSG00000221869(2), ENSG00000231925(2), ENSG00000256394(2), ENSG00000258790(2), ENSG00000266733(2), ENSG00000267534(2), ENSG00000274068(2), ENSG00000023318(2), ENSG00000026025(2), ENSG00000043355(2), ENSG00000058262(2), ENSG00000064393(2), ENSG00000065135(2), ENSG00000079335(2), ENSG00000080224(2), ENSG00000081721(2), ENSG00000100393(2), ENSG00000100429(2), ENSG00000106617(2), ENSG00000107485(2), ENSG00000107643(2), ENSG00000108384(2), ENSG00000111276(2), ENSG00000115137(2), ENSG00000120438(2), ENSG00000122691(2), ENSG00000123131(2), ENSG00000124613(2), ENSG00000130758(2), ENSG00000133105(2), ENSG00000133216(2), ENSG00000133392(2), ENSG00000135821(2), ENSG00000136826(2), ENSG00000138795(2), ENSG00000138801(2), ENSG00000139055(2), ENSG00000143627(2), ENSG00000144381(2), ENSG00000147133(2), ENSG00000148225(2), ENSG00000148677(2), ENSG00000149311(2), ENSG00000150907(2), ENSG00000152990(2), ENSG00000158805(2), ENSG00000160917(2), ENSG00000166501(2), ENSG00000168374(2), ENSG00000168757(2), ENSG00000169951(2), ENSG00000170364(2), ENSG00000171236(2), ENSG00000171509(2), ENSG00000175387(2), ENSG00000175544(2), ENSG00000176105(2), ENSG00000176601(2), ENSG00000177731(2), ENSG00000178919(2), ENSG00000179059(2), ENSG00000179674(2), ENSG00000180176(2), ENSG00000180210(2), ENSG00000183765(2), ENSG00000185130(2), ENSG00000185359(2), ENSG00000185697(2), ENSG00000186446(2), ENSG00000196172(2), ENSG00000196660(2), ENSG00000197647(2), ENSG00000198909(2), ENSG00000211455(2), ENSG00000256061(2), ENSG00000258472(2), ENSG00000258973(2), ENSG00000259371(2), ENSG00000269237(2), ENSG00000000460(2), ENSG00000004142(2), ENSG00000008324(2), ENSG00000010270(2), ENSG00000075240(2), ENSG00000080561(2), ENSG00000085514(2), ENSG00000085872(2), ENSG00000100991(2), ENSG00000103544(2), ENSG00000104970(2), ENSG00000106603(2), ENSG00000108523(2), ENSG00000109113(2), ENSG00000109272(2), ENSG00000109452(2), ENSG00000109738(2), ENSG00000110375(2), ENSG00000110756(2), ENSG00000111816(2), ENSG00000112659(2), ENSG00000113361(2), ENSG00000115239(2), ENSG00000117791(2), ENSG00000118434(2), ENSG00000118491(2), ENSG00000120159(2), ENSG00000120160(2), ENSG00000122694(2), ENSG00000124701(2), ENSG00000125650(2), ENSG00000127252(2), ENSG00000127743(2), ENSG00000127995(2), ENSG00000129646(2), ENSG00000130695(2), ENSG00000131037(2), ENSG00000131068(2), ENSG00000131233(2), ENSG00000131669(2), ENSG00000132429(2), ENSG00000133107(2), ENSG00000133134(2), ENSG00000133328(2), ENSG00000134297(2), ENSG00000134612(2), ENSG00000136542(2), ENSG00000137098(2), ENSG00000139767(2), ENSG00000143641(2), ENSG00000144410(2), ENSG00000144815(2), ENSG00000145194(2), ENSG00000145708(2), ENSG00000147027(2), ENSG00000148481(2), ENSG00000151388(2), ENSG00000151445(2), ENSG00000154760(2), ENSG00000155034(2), ENSG00000155622(2), ENSG00000157653(2), ENSG00000160325(2), ENSG00000160392(2), ENSG00000163013(2), ENSG00000163328(2), ENSG00000163444(2), ENSG00000163898(2), ENSG00000164054(2), ENSG00000165685(2), ENSG00000166145(2), ENSG00000166750(2), ENSG00000167646(2), ENSG00000168778(2), ENSG00000169085(2), ENSG00000169181(2), ENSG00000170265(2), ENSG00000170417(2), ENSG00000170777(2), ENSG00000171243(2), ENSG00000171357(2), ENSG00000172775(2), ENSG00000173715(2), ENSG00000174403(2), ENSG00000174448(2), ENSG00000175984(2), ENSG00000176435(2), ENSG00000176595(2), ENSG00000176641(2), ENSG00000176971(2), ENSG00000177576(2), ENSG00000177679(2), ENSG00000177946(2), ENSG00000179057(2), ENSG00000179304(2), ENSG00000179526(2), ENSG00000181240(2), ENSG00000181378(2), ENSG00000182327(2), ENSG00000183396(2), ENSG00000183666(2), ENSG00000183853(2), ENSG00000184208(2), ENSG00000184716(2), ENSG00000185156(2), ENSG00000186281(2), ENSG00000186297(2), ENSG00000186648(2), ENSG00000186792(2), ENSG00000186825(2), ENSG00000187123(2), ENSG00000187288(2), ENSG00000188707(2), ENSG00000188760(2), ENSG00000188959(2), ENSG00000189157(2), ENSG00000189182(2), ENSG00000196312(2), ENSG00000196576(2), ENSG00000196800(2), ENSG00000196990(2), ENSG00000197364(2), ENSG00000197568(2), ENSG00000197617(2), ENSG00000197870(2), ENSG00000198003(2), ENSG00000198824(2), ENSG00000198883(2), ENSG00000204183(2), ENSG00000204347(2), ENSG00000205002(2), ENSG00000205464(2), ENSG00000205869(2), ENSG00000206557(2), ENSG00000213920(2), ENSG00000214413(2), ENSG00000214414(2), ENSG00000214617(2), ENSG00000214652(2), ENSG00000214694(2), ENSG00000215196(2), ENSG00000223658(2), ENSG00000224186(2), ENSG00000224807(2), ENSG00000226763(2), ENSG00000230426(2), ENSG00000232125(2), ENSG00000235453(2), ENSG00000237651(2), ENSG00000238210(2), ENSG00000240225(2), ENSG00000240764(2), ENSG00000241224(2), ENSG00000242221(2), ENSG00000243244(2), ENSG00000243696(2), ENSG00000244234(2), ENSG00000249992(2), ENSG00000250709(2), ENSG00000255819(2), ENSG00000255872(2), ENSG00000256966(2), ENSG00000259571(2), ENSG00000262304(2), ENSG00000267303(2), ENSG00000269713(2), ENSG00000270629(2), ENSG00000271043(2), ENSG00000271723(2), ENSG00000272899(2), ENSG00000274600(2), ENSG00000274808(2), ENSG00000275674(2), ENSG00000275700(2), ENSG00000277150(2), ENSG00000277322(2), ENSG00000278615(2), ENSG00000279073(2), ENSG00000279078(2), ENSG00000279493(2), ENSG00000130755(2), ENSG00000137767(2), ENSG00000152766(2), ENSG00000173193(2), ENSG00000109943(2), ENSG00000138413(1), ENSG00000237787(1), ENSG00000177504(1), ENSG00000204290(1), ENSG00000163293(1), ENSG00000177673(1), ENSG00000173421(1), ENSG00000185028(1), ENSG00000180999(1), ENSG00000262576(1), ENSG00000198947(1), ENSG00000179348(1), ENSG00000180090(1), ENSG00000130528(1), ENSG00000127249(1), ENSG00000126561(1), ENSG00000110042(1), ENSG00000183629(1), ENSG00000196388(1), ENSG00000157765(1), ENSG00000196748(1), ENSG00000159723(1), ENSG00000204070(1), ENSG00000131097(1), ENSG00000157551(1), ENSG00000158480(1), ENSG00000198478(1), ENSG00000182168(1), ENSG00000255524(1), ENSG00000107731(1), ENSG00000164123(1), ENSG00000132471(1), ENSG00000167588(1), ENSG00000127585(1), ENSG00000171722(1), ENSG00000219435(1), ENSG00000198157(1), ENSG00000127663(1), ENSG00000132792(1), ENSG00000212916(1), ENSG00000159884(1), ENSG00000281613(1), ENSG00000244020(1), ENSG00000095066(1), ENSG00000168243(1), ENSG00000102387(1), ENSG00000164142(1), ENSG00000187676(1), ENSG00000242019(1), ENSG00000008394(1), ENSG00000232388(1), ENSG00000102554(1), ENSG00000271793(1), ENSG00000273167(1), ENSG00000163209(1), ENSG00000170390(1), ENSG00000101425(1), ENSG00000159263(1), ENSG00000224940(1), ENSG00000181396(1), ENSG00000205858(1), ENSG00000215193(1), ENSG00000244242(1), ENSG00000167601(1), ENSG00000106012(1), ENSG00000187957(1), ENSG00000118729(1), ENSG00000166987(1), ENSG00000172738(1), ENSG00000261456(1), ENSG00000149090(1), ENSG00000172717(1), ENSG00000215717(1), ENSG00000075702(1), ENSG00000140950(1), ENSG00000168273(1), ENSG00000135324(1), ENSG00000114867(1), ENSG00000149499(1), ENSG00000181007(1), ENSG00000180834(1), ENSG00000135245(1), ENSG00000130119(1), ENSG00000188056(1), ENSG00000272196(1), ENSG00000189320(1), ENSG00000203870(1), ENSG00000204514(1), ENSG00000204713(1), ENSG00000186326(1), ENSG00000198221(1), ENSG00000126602(1), ENSG00000259417(1), ENSG00000176845(1), ENSG00000148803(1), ENSG00000140264(1), ENSG00000147588(1), ENSG00000160932(1), ENSG00000133433(1), ENSG00000183763(1), ENSG00000184368(1), ENSG00000106853(1), ENSG00000176619(1), ENSG00000124508(1), ENSG00000075218(1), ENSG00000167747(1), ENSG00000133872(1), ENSG00000183779(1), ENSG00000112559(1), ENSG00000154102(1), ENSG00000127419(1), ENSG00000172932(1), ENSG00000203778(1), ENSG00000223820(1), ENSG00000104825(1), ENSG00000196460(1), ENSG00000068654(1), ENSG00000157927(1), ENSG00000111424(1), ENSG00000186212(1), ENSG00000239887(1), ENSG00000180357(1), ENSG00000123892(1), ENSG00000165169(1), ENSG00000261857(1), ENSG00000162139(1), ENSG00000197448(1), ENSG00000268182(1), ENSG00000159184(1), ENSG00000008283(1), ENSG00000130147(1), ENSG00000147439(1), ENSG00000117226(1), ENSG00000073331(1), ENSG00000180229(1), ENSG00000160679(1), ENSG00000170627(1), ENSG00000182108(1), ENSG00000213445(1), ENSG00000125148(1), ENSG00000162512(1), ENSG00000183496(1), ENSG00000187122(1), ENSG00000101363(1), ENSG00000115008(1), ENSG00000121314(1), ENSG00000128683(1), ENSG00000213512(1), ENSG00000087157(1), ENSG00000102924(1), ENSG00000130643(1), ENSG00000132010(1), ENSG00000143158(1), ENSG00000164932(1), ENSG00000176919(1), ENSG00000179820(1), ENSG00000183826(1), ENSG00000197430(1), ENSG00000198542(1), ENSG00000243207(1), ENSG00000183833(1), ENSG00000091583(1), ENSG00000092068(1), ENSG00000106066(1), ENSG00000115844(1), ENSG00000116983(1), ENSG00000117601(1), ENSG00000118181(1), ENSG00000118194(1), ENSG00000127774(1), ENSG00000128578(1), ENSG00000129910(1), ENSG00000132382(1), ENSG00000133026(1), ENSG00000136943(1), ENSG00000138207(1), ENSG00000141505(1), ENSG00000141576(1), ENSG00000151366(1), ENSG00000155011(1), ENSG00000156049(1), ENSG00000156687(1), ENSG00000159210(1), ENSG00000161835(1), ENSG00000163697(1), ENSG00000163827(1), ENSG00000164220(1), ENSG00000164418(1), ENSG00000165959(1), ENSG00000170365(1), ENSG00000170855(1), ENSG00000171421(1), ENSG00000171843(1), ENSG00000174502(1), ENSG00000176177(1), ENSG00000176231(1), ENSG00000176244(1), ENSG00000180739(1), ENSG00000181029(1), ENSG00000182253(1), ENSG00000182752(1), ENSG00000184270(1), ENSG00000197562(1), ENSG00000213931(1), ENSG00000082458(1), ENSG00000099284(1), ENSG00000100348(1), ENSG00000109471(1), ENSG00000111725(1), ENSG00000112576(1), ENSG00000116539(1), ENSG00000118156(1), ENSG00000119684(1), ENSG00000125538(1), ENSG00000126012(1), ENSG00000128573(1), ENSG00000128908(1), ENSG00000130413(1), ENSG00000132964(1), ENSG00000136518(1), ENSG00000137285(1), ENSG00000139445(1), ENSG00000140465(1), ENSG00000143479(1), ENSG00000143761(1), ENSG00000144852(1), ENSG00000146006(1), ENSG00000146535(1), ENSG00000149923(1), ENSG00000158079(1), ENSG00000163577(1), ENSG00000166226(1), ENSG00000168280(1), ENSG00000170684(1), ENSG00000171956(1), ENSG00000172936(1), ENSG00000174963(1), ENSG00000183486(1), ENSG00000187144(1), ENSG00000197054(1), ENSG00000197561(1), ENSG00000198093(1), ENSG00000198742(1), ENSG00000204388(1), ENSG00000222014(1), ENSG00000261459(1), ENSG00000267001(1), ENSG00000023892(1), ENSG00000095203(1), ENSG00000101246(1), ENSG00000103042(1), ENSG00000104055(1), ENSG00000105784(1), ENSG00000106178(1), ENSG00000106609(1), ENSG00000120685(1), ENSG00000124116(1), ENSG00000129422(1), ENSG00000130783(1), ENSG00000132823(1), ENSG00000133030(1), ENSG00000133131(1), ENSG00000134207(1), ENSG00000134551(1), ENSG00000137441(1), ENSG00000140478(1), ENSG00000140479(1), ENSG00000140545(1), ENSG00000142511(1), ENSG00000144229(1), ENSG00000148814(1), ENSG00000149150(1), ENSG00000150201(1), ENSG00000152154(1), ENSG00000155066(1), ENSG00000158423(1), ENSG00000162062(1), ENSG00000162399(1), ENSG00000164674(1), ENSG00000165985(1), ENSG00000166926(1), ENSG00000168675(1), ENSG00000168903(1), ENSG00000168967(1), ENSG00000171695(1), ENSG00000172986(1), ENSG00000173269(1), ENSG00000173548(1), ENSG00000173597(1), ENSG00000175183(1), ENSG00000175967(1), ENSG00000177994(1), ENSG00000178457(1), ENSG00000179002(1), ENSG00000183742(1), ENSG00000185105(1), ENSG00000185955(1), ENSG00000186481(1), ENSG00000189127(1), ENSG00000196091(1), ENSG00000198685(1), ENSG00000204511(1), ENSG00000214575(1), ENSG00000226887(1), ENSG00000227268(1), ENSG00000241690(1), ENSG00000251537(1), ENSG00000253117(1), ENSG00000261794(1), ENSG00000265107(1), ENSG00000269405(1), ENSG00000269476(1), ENSG00000273590(1), ENSG00000278023(1), ENSG00000125910(1), ENSG00000136147(1), ENSG00000137474(1), ENSG00000142453(1), ENSG00000155849(1), ENSG00000156587(1), ENSG00000137203(1), ENSG00000159110(1), ENSG00000162496(1), ENSG00000166920(1), ENSG00000186431(1), ENSG00000120053(1), ENSG00000134627(1), ENSG00000138495(1), ENSG00000142634(1), ENSG00000147180(1), ENSG00000204618(1), ENSG00000269026(1), ENSG00000075426(1), ENSG00000149269(1), ENSG00000198739(1), ENSG00000013392(1), ENSG00000118922(1), ENSG00000121957(1), ENSG00000172350(1), ENSG00000274267(1)

5.4 Best C-index test in all runs

Best Elastic Net model (C-Index test)

[INFO] Coefs. list

[1] “ADAMDEC1, ADGRG5, ANG, ARMH1, B2M, CALHM1, CCL8, CIITA, CRIP1, CXCL9, ETV3L, GBP1, GBP2, GBP4, GJA10, HAPLN3, HLA-DQA1, HLA-DQB1, HOXB6, IFITM1, IL21R, KIR2DL4, KLRD1, MAP3K7CL, MEI1, MZB1, NLRP6, OR2M4, PATL2, PIM2, PLA2G2D, PSME2, RNF213, SLC25A52, SLC38A11, SULT1E1, TNFRSF4, TRIM69, ZBP1, ZNF667, ZRSR2”

Test set

Full set

Best Hub model (C-Index test)

[INFO] Coefs. list

[1] “ACTL7B, ACTL8, ACTR1B, ALB, CAD, CD8A, CDK2, CDK5, CTNNB1, EGFR, ESR1, FAU, GAPDH, HSP90AA1, ICAM1, IMPDH2, INSR, ISG15, KIT, LCK, LRRK2, MAPK1, MAPK14, MAPK3, MYH14, OAS1, OASL, PIM2, PPP3CC, PRKCG, RAB2B, RASD2, RHOA, RHOBTB2, RHOC, RHOJ, RRAS, TP53, TSPO, TUBB2A, UBC, UBD, UBL4A”

Test set

Full set

Best Orphan model (C-Index test)

[INFO] Coefs. list

[1] “AC114490.2, ADAMDEC1, ADGRG5, ARMH1, C11orf21, CALHM1, CAPS, CCDC8, CCL5, CCL8, CRIP1, CXorf58, CYBC1, ETV3L, FCRL6, GBA3, GBP5, GJA10, GRIPAP1, HAPLN3, HLA-DQA1, HSH2D, KIR2DL4, LCN9, LGALS17A, LINC00324, LINC00336, MAP3K7CL, MEI1, MZB1, NEURL3, NLRP6, PATL2, PLA2G2D, REC8, RNASE4, SLC25A52, SLC38A11, SLC66A1L, TIGIT, ZNF320, ZNF730”

Test set

Full set

5.5 Best Log-rank test in all runs

Best Elastic net (Log-rank test)

[INFO] Coefs. list

[1] “AACS, AC005520.1, ACTL8, ACY3, AIP, AL136295.1, ANG, APH1B, ASZ1, ATP13A4, B2M, BPY2B, C1orf185, C1QTNF8, C3orf49, CA11, CALHM1, CCL5, CCL8, CCNF, CD274, CD74, CDIP1, CNGA1, CPLX3, CRIP1, CTRB1, CXCL11, CXCL9, CXorf58, CYP26C1, EARS2, FANCE, FERD3L, FERMT3, FOLR1, FZD5, GBA3, GBP2, GJA10, GLIPR1L1, GLIS3, GRIPAP1, HAPLN3, HLA-B, HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB5, HLA-F, HORMAD2, HPDL, HSFY2, IFFO1, IFITM1, IL18BP, IRF1, ISCU, ISL1, JPT2, KCNJ15, KCNMB1, KIR2DL4, KRT19, LCN9, LINC00324, LINC00336, MAGEB2, MAP3K7CL, MDGA1, MID1IP1, MIR99AHG, MROH2A, NIPAL1, NLRC5, NLRP6, NOTCH3, NTNG2, NYAP2, OR3A1, PAQR7, PARP8, PGGHG, PHF21B, PKIG, PPIAL4G, PPP1R12C, PPP3CC, PRM2, PSME2, RAB2B, REC8, RTL10, S100G, SCAMP5, SCNN1G, SLA2, SLC25A52, SLC34A2, SLC38A11, SLC7A2, SSTR2, SYDE2, SYT14, TARM1, TICRR, TMPRSS7, TRIM69, TTC39A, UNC13A, UTS2, WDR77, ZBP1, ZNF197, ZNF492, ZNF69, ZNF724, ZNF730, ZNF844, ZRSR2”

Test set

Full set

Best Hub model (Log-rank test)

[INFO] Coefs. list

[1] “ACTL6B, ACTL7B, ACTL8, ACTR1B, ALB, CD8A, CDK2, CDK3, CDK4, CIB4, DECR1, EGFR, EPHB1, ESR1, FAU, FGF2, GAPDH, GART, HSP90AA1, IMPDH2, INSR, KIT, LRRK2, MAPK1, MAPK14, MET, MYH14, OAS1, OAS2, OASL, PPP3CC, RAB25, RAC3, RAD51D, RHOJ, RHOV, TP53, TSPO, TUBA1C, TUBB2A, UBC, UBD, UBL4A, UBL4B, UMPS, ZFAND4”

Test set

Full set

Best Orphan model (Log-rank test)

[INFO] Coefs. list

[1] “ACY3, ADGRG5, BPY2B, BTN3A3, CCL5, CCL8, CRIP1, EARS2, FANCE, FERD3L, GBP5, GJA10, GRIPAP1, HAPLN3, HCP5, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-F, HPDL, HSH2D, IFITM1, IRF1-AS1, JPT2, KIR2DL4, LGALS17A, LINC00324, LINC00336, MAP3K7CL, NKG7, NLRC5, NLRP6, NYAP2, PARP8, REC8, RTL10, RUFY4, SLA2, SLC25A52, SLC38A11, TARM1, TICRR, TTC39A, ZNF730”

Test set

Full set

NULL

6 Parameters for the report

## [INFO]          balanced.sets: TRUE
## [INFO]        calc.params.old: FALSE
## [INFO]           coding.genes: TRUE
## [INFO]     degree.correlation: pearson
## [INFO]          degree.cutoff:       0.000
## [INFO]            degree.type: string
## [INFO]      degree.unweighted: TRUE
## [INFO]      handle.duplicates: keep_first
## [INFO]                   log2: TRUE
## [INFO]                n.cores:      14.000
## [INFO]          normalization: center
## [INFO]                 ntimes:    5000.000
## [INFO]                project: skcm.data.2018.09.11
## [INFO]                   seed:    1985.000
## [INFO]                 subset: Inf
## [INFO]   subtract.surv.column: days_to_submitted_specimen_dx
## [INFO]            target.vars: list(alpha = 0.1, vars = 116), list(alpha = 0.1, vars = 41), list(alpha = 0.1, vars = 111)
## [INFO]                 tissue: metastatic
## [INFO]                  train:       0.800